Blood-testis barrier and spermatogenesis: lessons from genetically-modified mice.
Blood-testis barrier and spermatogenesis: lessons from genetically-modified mice.
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血睾屏障和精子发生：转基因小鼠的教训
DOI：
10.4103/1008-682x.125401
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发表时间：
2014-07
影响因子：
2.9
通讯作者：
Shi QH
中科院分区：
文献类型：
--
作者：
Jiang XH;Bukhari I;Zheng W;Yin S;Wang Z;Cooke HJ;Shi QH
血-睾丸屏障(BTB)位于睾丸内相邻的支持细胞之间，为生精管内减数分裂和减数分裂后生殖细胞的发育和成熟创造了独特的微环境。它是一种复合的蛋白质结构，由几种类型的细胞连接组成，包括紧密连接(TJ)、黏附连接和缝隙连接(GJS)。一些连接蛋白作为BTB的结构蛋白发挥作用，另一些则具有调节作用。编码这些蛋白的基因的缺失或功能沉默可能会扰乱BTB，这可能会对减数分裂和减数分裂后的细胞造成免疫或其他损害，最终导致生精停滞和不育。在这篇综述中，我们将总结在转基因小鼠模型中关于BTB结构和功能的研究结果，并讨论未来的前景。
The blood-testis barrier (BTB) is found between adjacent Sertoli cells in the testis where it creates a unique microenvironment for the development and maturation of meiotic and postmeiotic germ cells in seminiferous tubes. It is a compound proteinous structure, composed of several types of cell junctions including tight junctions (TJs), adhesion junctions and gap junctions (GJs). Some of the junctional proteins function as structural proteins of BTB and some have regulatory roles. The deletion or functional silencing of genes encoding these proteins may disrupt the BTB, which may cause immunological or other damages to meiotic and postmeiotic cells and ultimately lead to spermatogenic arrest and infertility. In this review, we will summarize the findings on the BTB structure and function from genetically-modified mouse models and discuss the future perspectives.