Asymmetric total synthesis of (+)-fumimycin via 1,2-addition to ketimines
Asymmetric total synthesis of (+)-fumimycin via 1,2-addition to ketimines
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DOI：
10.1039/c0cc03399e
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发表时间：
2010-01-01
影响因子：
4.9
通讯作者：
Braese, Stefan
中科院分区：
文献类型：
--
作者：
Gross, Patrick J.;Furche, Filipp;Braese, Stefan
首次完成了伏马霉素的不对称全合成。作为一个关键步骤，甲基Grignard试剂与酮亚胺的1，2-加成与奎宁作为添加剂。用CD光谱结合含时密度泛函计算确定了（+）-烟霉素的绝对构型。
The first asymmetric total synthesis of fumimycin was accomplished. As a key step, a 1,2-addition of methyl Grignard reagents to ketimines with quinine as additive was employed. The absolute configuration of (+)-fumimycin was determined by CD-spectroscopy combined with time-dependent density functional calculations.