A voxel-by-voxel analysis of [18F]setoperone PET data shows no substantial serotonin 5-HT2A receptor changes in schizophrenia
A voxel-by-voxel analysis of [18F]setoperone PET data shows no substantial serotonin 5-HT2A receptor changes in schizophrenia
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[18F]setoperone PET 数据的逐体素分析显示精神分裂症中血清素 5-HT2A 受体没有显着变化
DOI：
10.1016/s0165-1781(00)00198-0
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发表时间：
2000
期刊：
影响因子：
--
通讯作者：
S. Kapur
中科院分区：
文献类型：
--
作者：
N. Verhoeff;J. Meyer;A. Kecojevic;D. Hussey;Ralph Lewis;J. Tauscher;R. Zipursky;S. Kapur
几项尸检研究报告了精神分裂症患者的5-HT 2AR受体（5-HT 2AR）的区域性降低。最近的两项[18F]setoperone正电子发射断层扫描（PET）研究未证实这一点。在这两项研究中，使用了相对较大的感兴趣区域（ROI）;因此，可能遗漏了某些脑区的5-HT 2AR变化。因此，使用统计参数映射（SPM）逐体素分析一项研究的数据。我们还使用这种方法来检查5-HT 2AR结合电位（BP）和五个PANSS衍生的因素：消极，积极，激活，焦虑和自闭症的关注之间的关系。对13例精神分裂症患者（10例抗精神病药物初治，3例未使用抗精神病药物; 11例男性，2例女性;年龄31±7岁）和35例年龄匹配的对照受试者（15例男性，20例女性;年龄30±7岁）进行了扫描。使用伪平衡比率法，根据[18 F]司托哌隆推注后65 - 90 min之间获得的PET数据，测定每个体素的5-HT 2AR BP。使用配体特异性模板对所得的参数5-HT 2AR BP图像进行空间归一化。使用SPM 99进行协方差分析，以年龄作为协变量。在对精神分裂症的影响和5-HT 2AR BP与五个因素之间的偏相关性的检验中，在聚类或体素水平上校正的P值<0.05被认为是显著的。患者与对照组之间无显著性差异，5-HT 2 AR BP与5个因素中的任何一个均无显著相关性。因此，与先前的ROI研究一致，逐体素分析证实了精神分裂症患者和对照组之间缺乏实质性的5-HT 2AR BP差异。
Several postmortem studies have reported regionally localized decreases in serotonin2Areceptors (5-HT2AR) in schizophrenia. This was not confirmed by two recent [18F]setoperone positron emission tomography (PET) studies. In these two studies relatively large regions of interest (ROIs) were used; hence, 5-HT2AR changes may have been missed in some brain areas. Therefore, data from one study were analyzed on a voxel-by-voxel basis using Statistical Parametric Mapping (SPM). We also used this method to examine the relationship between 5-HT2AR binding potential (BP) and five PANSS-derived factors: negative, positive, activation, dysphoric and autistic preoccupation. Thirteen schizophrenic patients (10 antipsychotic-naı̈ve, 3 antipsychotic-free; 11 M, 2 F; age 31±7 years) and 35 age-matched control subjects (15 M, 20 F; age 30±7 years) were scanned. The 5-HT2AR BP was determined for each voxel using the pseudoequilibrium ratio method on PET data obtained between 65 and 90 min after [18F]setoperone bolus injection. The resulting parametric 5-HT2AR BP images were spatially normalized using a ligand specific template. Analyses of covariance were done using SPM99 with age as covariate. In tests for the effect of schizophrenia and for partial correlations between 5-HT2AR BP and the five factors, corrected P values <0.05 at cluster or voxel level were considered significant. No significant differences were detected between patients and control subjects, and no significant correlations were observed between 5-HT2AR BP and any of the five factors. Thus, in agreement with the previous ROI studies, voxel-by-voxel analysis confirmed the lack of substantial 5-HT2AR BP differences between schizophrenic patients and control subjects.
典型和非典型抗精神病药物对大鼠大脑皮层5-HT2受体密度的影响。
影响因子：
6.1
作者：
Matsubara,S;Meltzer,HY
通讯作者：
Meltzer,HY
精神分裂症和含有小白蛋白的皮质局部回路神经元。
DOI：
10.1176/ajp.154.7.1013
发表时间：
1997
期刊：
The American journal of psychiatry
影响因子：
--
作者：
Woo,TU;Miller,JL;Lewis,DA
通讯作者：
Lewis,DA