Composite of Au nanoparticles and molecularly imprinted polymer as a sensing material
Composite of Au nanoparticles and molecularly imprinted polymer as a sensing material
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DOI：
10.1021/ac034788q
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发表时间：
2004-03-01
影响因子：
7.4
通讯作者：
Sugimoto, N
中科院分区：
文献类型：
--
作者：
Matsui, J;Akamatsu, K;Sugimoto, N
报道了一种新型的分子印迹聚合物--固定化Au纳米粒子（Au-MIP）传感材料。传感机制是基于固定在印迹聚合物中的纳米粒子的可变接近度，其表现出对给定分析物的选择性结合，伴随着溶胀，导致固定的Au纳米粒子的等离子体吸收带的蓝移。使用肾上腺素作为模型分析物，它表明，分子印迹有效地提高了灵敏度和选择性，因此，Au-MIP选择性地检测5 μ M的分析物。分子印迹和基于纳米颗粒的传感系统的组合被证明是一种通用的策略，用于构建传感材料在一个定制的方式，由于广泛的适用性的印迹技术和独立的传感机制从分析物识别系统。
A molecularly imprinted polymer with immobilized Au nanoparticles (Au-MIP) is reported as a novel type of sensing material. The sensing mechanism is based upon the variable proximity of the An nanoparticles immobilized in the imprinted polymer, which exhibits selective binding of a given analyte accompanied by swelling that causes a blue-shift in the plasmon absorption band of the immobilized Au nanoparticles. Using adrenaline as the model analyte, it was shown that molecular imprinting effectively enhanced the sensitivity and selectivity, and accordingly, Au-MIP selectively detects the analyte at 5 muM. The combination of molecular imprinting and the An nanoparticle-based sensing system was shown to be a general strategy for constructing sensing materials in a tailor-made fashion due to wide applicability of the imprinting technique and the independence of the sensing mechanism from the analyte recognition system.