Variation in the safety of induced pluripotent stem cell lines
Variation in the safety of induced pluripotent stem cell lines
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DOI：
10.1038/nbt.1554
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发表时间：
2009-08-01
影响因子：
46.9
通讯作者：
Yamanaka, Shinya
中科院分区：
文献类型：
--
作者：
Miura, Kyoko;Okada, Yohei;Yamanaka, Shinya
我们评估了以11种不同方式衍生的36种小鼠诱导多能干细胞（iPS）细胞系产生的次级神经球（SNS）的畸胎瘤形成倾向。胚胎成纤维细胞来源的iPS细胞的SNS的畸胎瘤形成与胚胎干（ES）细胞的SNS的畸胎瘤形成相似。与此相反，SNS从iPS细胞来源于不同的成人组织，其畸胎瘤形成的倾向，这与未分化细胞的持久性差异很大。
We evaluated the teratoma-forming propensity of secondary neurospheres (SNS) generated from 36 mouse induced pluripotent stem (iPS) cell lines derived in 11 different ways. Teratoma-formation of SNS from embryonic fibroblast-derived iPS cells was similar to that of SNS from embryonic stem (ES) cells. In contrast, SNS from iPS cells derived from different adult tissues varied substantially in their teratoma-forming propensity, which correlated with the persistence of undifferentiated cells.