Cytogenetic events after bone marrow transplantation for chronic myeloid leukemia in chronic phase.
Cytogenetic events after bone marrow transplantation for chronic myeloid leukemia in chronic phase.
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慢性粒细胞白血病慢性期骨髓移植后的细胞遗传学事件。
DOI：
10.1182/blood.v71.5.1179.1179
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发表时间：
1988
期刊：
影响因子：
20.3
通讯作者：
JM Goldman
中科院分区：
文献类型：
--
作者：
CK Arthur;J. Apperley;AP Guo;F. Rassool;L. Gao;JM Goldman
对48例Ph染色体阳性慢性粒细胞白血病（CML）患者进行异基因骨髓移植（BMT），移植后定期进行骨髓细胞遗传学检查。20名患者接受了来自异性供体的骨髓细胞。骨髓移植后，48例患者中有24例（50%）发现了Ph+骨髓中期细胞; 16例患者在早期（1年内）首次发现，8例患者在晚期（骨髓移植后1年以上）首次发现。骨髓移植后Ph阳性发生更常见于T细胞耗竭的接受者比非耗竭骨髓（19/28 v5/20）。在4例病例中，Ph+中期细胞仅在BMT后短暂发现;在11例病例中，Ph+中期细胞持续存在，但随后未发生血液学复发;在9例病例中，Ph+中期细胞的发现与血液学复发一致或在血液学复发之前。2例供体来源细胞染色体形态异常。在供体来源的细胞中未发现复发。我们的数据表明，受体和供体来源的细胞之间的关系是复杂的：白血病的治愈可能取决于骨髓移植后几个月或几年的因素。
Forty-eight patients treated by allogeneic bone marrow transplantation (BMT) for Philadelphia (Ph) chromosome-positive chronic myeloid leukemia in chronic phase had serial cytogenetic studies of marrow performed at intervals after transplant. Twenty patients received marrow cells from donors of opposite sex. Ph+ marrow metaphases were identified in 24 of 48 (50%) of patients after BMT; they were first seen early (within 1 year) in 16 cases and late (greater than 1 year after BMT) in eight cases. Ph-positivity after BMT occurred more commonly in recipients of T-depleted than nondepleted marrow (19 of 28 v 5 of 20). In 4 cases the Ph+ metaphases were found only transiently after BMT; in 11 cases the Ph+ metaphases have persisted but hematologic relapse has not ensued; in 9 cases the finding of Ph+ metaphases coincided with or preceded hematologic relapse. Chromosomes in cells of donor origin had morphological abnormalities in two cases. No relapses were identified in cells of donor origin. Our data suggest that the relationship between cells of recipient and donor origin is complex: cure of leukemia may depend on factors that operate for some months or years after BMT.
急性白血病全身照射和骨髓移植后内源干细胞再生导致混合造血嵌合。
影响因子：
6.2
作者：
Branch,DR;Gallagher,MT;Forman,SJ;Winkler,KJ;Petz,LD;Blume,KG
通讯作者：
Blume,KG
影响因子：
39.2
作者：
THOMAS, ED;CLIFT, RA;WITHERSPOON, R
通讯作者：
WITHERSPOON, R
不同剂量率和分次全身照射的放射生物学基础：造血细胞的修复能力。
DOI：
10.1016/0360-3016(81)90195-4
发表时间：
1981
期刊：
International journal of radiation oncology, biology, physics
影响因子：
--
作者：
Song,CW;Kim,TH;Khan,FM;Kersey,JH;Levitt,SH
通讯作者：
Levitt,SH