Duration of injury correlates with necrosis in caerulein-induced experimental acute pancreatitis: implications for pathophysiology
Duration of injury correlates with necrosis in caerulein-induced experimental acute pancreatitis: implications for pathophysiology
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DOI：
10.1111/iep.12081
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发表时间：
2014-06-01
影响因子：
3
通讯作者：
Roy, Tara S.
中科院分区：
文献类型：
--
作者：
Jacob, Tony G.;Raghav, Rahul;Roy, Tara S.
胰腺腺泡细胞坏死是严重胰腺炎的标志，坏死程度是其预后的一个指标。在瑞士白化小鼠中，我们研究了损伤的剂量和持续时间是否与严重程度相关，特别是在坏死方面。除对照组1 （G1）外，2、3组每h注射4次小毛蛋白，分别于5 h （G2）、9 h （G3）处死；4组每h注射8次小毛蛋白，9 h处死（G4）。采用组织病理学和生化方法评价胰腺炎的严重程度。3、4组胰腺炎组织病理学评分明显高于1、2组(4 vs. 1,4 vs. 2,3 vs. 1,3 vs. 2
Pancreatic acinar cell necrosis is indicative of severe pancreatitis and the degree of necrosis is an index of its outcome. We studied whether the dose and duration of injury correlates with severity, particularly in terms of necrosis, in caerulein-induced acute pancreatitis (AP) in Swiss albino mice. In addition to control group 1 (G1), groups 2 and 3 received four injections of caerulein every hour but were sacrificed at five hours (G2) and nine hours (G3) respectively, and group 4 received eight injections and was sacrificed at nine hours (G4). The severity of pancreatitis was assessed histopathologically and biochemically. The histopathological scores of pancreatitis in groups 3 and 4 were significantly higher than in groups 1 and 2 (4 vs. 1, 4 vs. 2, 3 vs. 1, 3 vs. 2; P