Adenosine A2A, but not A1, receptors mediate the arousal effect of caffeine
Adenosine A2A, but not A1, receptors mediate the arousal effect of caffeine
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DOI：
10.1038/nn1491
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发表时间：
2005-07-01
影响因子：
25
通讯作者：
Hayaishi, O
中科院分区：
文献类型：
--
作者：
Huang, ZL;Qu, WM;Hayaishi, O
咖啡因是茶、咖啡和可乐中的一种成分，会让人清醒。它作为一种拮抗剂与腺苷A(1)和A(2A)受体结合，但介导咖啡因诱导觉醒的受体亚型尚不清楚。在这里，我们报告咖啡因5，10和15 mg kg(-1)增加了野生型小鼠和A(1)受体基因敲除小鼠的觉醒，但在A(2A)受体基因敲除小鼠中没有。因此，咖啡因诱导的觉醒依赖于腺苷A(2A)受体。
Caffeine, a component of tea, coffee and cola, induces wakefulness. It binds to adenosine A(1) and A(2A) receptors as an antagonist, but the receptor subtype mediating caffeine-induced wakefulness remains unclear. Here we report that caffeine at 5, 10 and 15 mg kg(-1) increased wakefulness in both wild-type mice and A(1) receptor knockout mice, but not in A(2A) receptor knockout mice. Thus, caffeine-induced wakefulness depends on adenosine A(2A) receptors.