Nucleotide sequence and genome organization of human papillomavirus type 5.
Nucleotide sequence and genome organization of human papillomavirus type 5.
复制标题
人乳头瘤病毒 5 型的核苷酸序列和基因组结构。
DOI：
10.1016/0042-6822(87)90263-7
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发表时间：
1987
期刊：
影响因子：
3.7
通讯作者：
Faras,AJ
中科院分区：
文献类型：
--
作者：
Zachow,KR;Ostrow,RS;Faras,AJ
人乳头瘤病毒（HPV）5型与疣状表皮发育不良（EV）疾病的良性和恶性病变有关。由于HPV-5的存在与这些患者的恶性进展之间存在很强的相关性，我们已经阐明了HPV-5基因组的核苷酸序列。HPV-5基因组的大小为7746个核苷酸，其组织与其他乳头瘤病毒相似。HPV-5基因组与另一种EV相关乳头瘤病毒HPV-8具有广泛的序列同源性，尽管HPV-5似乎含有至少一个额外的开放阅读框。
Human papillomavirus (HPV) type 5 is associated with benign and malignant lesions of the disease epidermodysplasia verruciformis (EV). Because of the strong correlation between the presence of HPV-5 and malignant progression in these patients, we have elucidated the nucleotide sequence of the HPV-5 genome. The size of the HPV-5 genome is 7746 nucleotides and its organization is similar to that of other papillomaviruses. The HPV-5 genome exhibits extensive sequence homology with another EV-associated papillomavirus, HPV-8, although HPV-5 appears to contain at least one additional open reading frame.