P3 in alcoholics with disordered regulation of aggression.
P3 in alcoholics with disordered regulation of aggression.
复制标题
P3 存在于攻击性调节紊乱的酗酒者中。
DOI：
10.1016/0165-1781(88)90157-6
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发表时间：
1988
影响因子：
11.3
通讯作者：
Lieber,CS
中科院分区：
文献类型：
--
作者：
Branchey,MH;Buydens-Branchey,L;Lieber,CS
酗酒者被发现在事件相关电位的P3成分中表现出缺陷，这些事件相关电位是使用信息加工范式获得的。然而，酒精中毒患者构成了一个异质性群体。在一项研究中，P3电压在酗酒者的情绪和攻击控制障碍的亚组，我们观察到这些电压的显着下降，在患者的终身历史的攻击行为。有身体暴力犯罪史的患者P3波幅最低。同样的患者也有一个父亲酗酒率显着高于观察到的其他人群。因此，他们可以被归类为2型酗酒者，因为在这种酒精亚型中描述了反社会行为的倾向和酗酒的高遗传负荷。这些数据可能表明，P3振幅的递减表征了一个亚组的酗酒者与侵略的失调调节。或者，P3缺陷可能与酗酒者的某些精神病理学状况有关，而不是与酗酒本身有关。
Alcoholics have been found to show deficits in the P3 component of event-related potentials obtained using information-processing paradigms. However, alcoholic patients form a heterogeneous population. In a study of P3 voltages in subgroups of alcoholics with disorders in mood and aggression control, we observed significant decrements in these voltages in patients with lifelong histories of aggressive behavior. Patients with histories of incarceration for crimes involving physical violence had the lowest P3 amplitudes. The same patients also had a rate of paternal alcoholism significantly higher than that observed in the rest of the population. They could thus be classified as type 2 alcoholics, as a tendency to antisocial behavior and a high genetic loading for alcoholism have been described in this alcoholic subtype. These data could indicate that decrements in P3 amplitude characterize a subgroup of alcoholics with a disordered regulation of aggression. Alternatively, P3 deficits could be associated with some psychopathological conditions in individuals who abuse alcohol rather than with alcoholism, per se.