Changes in fentanyl demand following naltrexone, morphine, and buprenorphine in male rats
Changes in fentanyl demand following naltrexone, morphine, and buprenorphine in male rats
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DOI：
10.1016/j.drugalcdep.2019.107804
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发表时间：
2020-02-01
影响因子：
4.2
通讯作者：
Bardo, Michael T.
中科院分区：
文献类型：
--
作者：
Hammerslag, Lindsey R.;Hofford, Rebecca S.;Bardo, Michael T.
背景资料：阿片类药物使用障碍（OUD）患者对阿片类药物的经济需求水平很高，消费水平很高，对价格变化相对不敏感。由于用于治疗OUD的药物辅助治疗（MAT）作为拮抗剂或激动剂在μ阿片受体，他们可能会改变价格和阿片类药物intake.Methods之间的关系：本研究探讨了需求的一种常见的滥用合成处方阿片类药物，芬太尼，在雄性大鼠皮下注射后。用纳洛酮（0.1-1.0 mg/kg）、吗啡（0.3-3.0 mg/kg）或丁丙诺啡（0.3-3.0 mg/kg）预处理。我们将需求曲线标准化为最低价格的摄入量，并估计了对弹性的影响（对价格变化的敏感性）。大鼠首先接受训练，以获得芬太尼（5 μ g/kg/输注）的固定比例的时间表，然后他们接受了日常训练的阈值程序，旨在产生会话内的需求曲线估计。大鼠接受了14个阈值会议之前，进行了一系列的测试，包括每种药物，在每个dose.Results：弹性增加预处理纳洛酮，吗啡或丁丙诺啡。吗啡也减少了初始摄入量，当时芬太尼的价格最低。相反，纳洛酮增加了初始摄入量（根据倒U形曲线）。纳洛酮的影响没有持续后，测试会议，但吗啡和丁丙诺啡继续影响需求弹性24小时或48小时后，tests.Conclusions：这些结果表明，芬太尼的需求是敏感的阿片受体的药物类用于MAT在人类的封锁或激活。
Background: Individuals with opioid use disorder (OUD) exhibit high levels of economic demand for opioids, with high levels of consumption and relative insensitivity to changes in price. Because the medications used to treat OUD in medication-assisted therapy (MAT) act as antagonists or agonists at mu opioid receptors, they may alter the relationship between price and opioid intake.Methods: This study examined demand for a commonly abused synthetic prescription opioid, fentanyl, in male rats following s.c. pre-treatment with naltrexone (0.1-1.0 mg/kg), morphine (0.3-3.0 mg/kg) or buprenorphine (0.3-3.0 mg/kg). We normalized demand curves to intake at the lowest price and estimated effects on elasticity (sensitivity to changes in price). Rats were first trained to earn fentanyl (5 mu g/kg/infusion) on a fixed ratio schedule, then they underwent daily training under a threshold procedure designed to produce within-session demand curve estimates. Rats received 14 threshold sessions before undergoing a series of tests encompassing each drug, at each dose.Results: Elasticity was increased by pretreatment with naltrexone, morphine or buprenorphine. Morphine also decreased initial intake, when the price for fentanyl was lowest. In contrast, initial intake was increased by naltrexone (according to an inverted-U shaped curve). The effects of naltrexone did not persist after the test session, but morphine and buprenorphine continued affecting demand elasticity 24 h or 48 h after the test, respectively.Conclusions: These results indicate that fentanyl demand is sensitive to blockade or activation of opioid receptors by the drug classes used for MAT in humans.