The International Database of HOme blood pressure in relation to Cardiovascular Outcome (IDHOCO): moving from baseline characteristics to research perspectives.
The International Database of HOme blood pressure in relation to Cardiovascular Outcome (IDHOCO): moving from baseline characteristics to research perspectives.
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DOI：
10.1038/hr.2012.97
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发表时间：
2012-11
影响因子：
5.4
通讯作者：
Staessen, Jan A.
中科院分区：
文献类型：
--
作者：
Niiranen, Teemu J.;Thijs, Lutgarde;Asayama, Kei;Johansson, Jouni K.;Ohkubo, Takayoshi;Kikuya, Masahiro;Boggia, Jose;Hozawa, Atsushi;Sandoya, Edgardo;Stergiou, George S.;Tsuji, Ichiro;Jula, Antti M.;Imai, Yutaka;Staessen, Jan A.
本研究的目的是建立一个关于家庭血压与心血管结局关系的国际数据库（IDHOCO）。该数据库的主要目标是确定自测家庭血压（BP）的基于结果的诊断阈值。次要目的包括研究白大衣和隐蔽性高血压、早晨和晚上血压、血压和心率变异性以及家庭动脉僵硬度指数的预测价值。我们还旨在确定家庭血压测量的最佳时间表，以提供最准确的风险分层。符合条件的研究是基于人群的，具有可供分析的致命性和非致命性结局，符合伦理标准，并且先前已在同行评审期刊上发表。在基于个体受试者数据的荟萃分析中，复合和病因特异性心血管事件将与通过家庭血压测量得出的各种指标相关。分析将按队列分层，并根据门诊BP和已确定的心血管风险因素进行调整。该数据库包括来自日本Ohasama（n = 2777）、芬兰（n = 2075）、日本Tsurugaya（n = 836）、希腊Didima（n = 665）和乌拉圭蒙得维的亚（n = 400）招募的5个队列的6753例受试者。在这五个队列中，在总共62106人年的随访期间（平均9.2年），852名受试者死亡，740名参与者发生了致命或非致命性心血管事件。IDHOCO提供了一个独特的机会来研究几个在个别研究中无法可靠研究的假设。这些分析的结果应有助于临床医生参与管理的患者怀疑或建立高血压。
The objective of this study is to construct an International Database of HOme blood pressure in relation to Cardiovascular Outcome (IDHOCO). The main goal of this database is to determine outcome-based diagnostic thresholds for the self-measured home blood pressure (BP). Secondary objectives include investigating the predictive value of white-coat and masked hypertension, morning and evening BP, BP and heart rate variability, and the home arterial stiffness index. We also aim to determine an optimal schedule for home BP measurements that provides the most accurate risk stratification. Eligible studies are population-based, have fatal as well as nonfatal outcomes available for analysis, comply with ethical standards, and have been previously published in peer-reviewed journals. In a meta-analysis based on individual subject data, composite and cause-specific cardiovascular events will be related to various indexes derived by home BP measurement. The analyses will be stratified by a cohort and adjusted for the clinic BP and established cardiovascular risk factors. The database includes 6753 subjects from five cohorts recruited in Ohasama, Japan (n = 2777); Finland (n = 2075); Tsurugaya, Japan (n = 836); Didima, Greece (n = 665); and Montevideo, Uruguay (n = 400). In these five cohorts, during a total of 62 106 person-years of follow-up (mean 9.2 years), 852 subjects died and 740 participants experienced a fatal or nonfatal cardiovascular event. IDHOCO provides a unique opportunity to investigate several hypotheses that could not reliably be studied in individual studies. The results of these analyses should be of help to clinicians involved in the management of patients with suspected or established hypertension.
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影响因子：
8.3
作者：
Johansson, Jouni K.;Niiranen, Teemu J.;Jula, Antti M.
通讯作者：
Jula, Antti M.
影响因子：
8.3
作者：
Asayama, K;Ohkubo, T;Imai, Y
通讯作者：
Imai, Y
影响因子：
8.3
作者：
Agarwal, Rajiv;Bills, Jennifer E.;Light, Robert P.
通讯作者：
Light, Robert P.
影响因子：
1.3
作者：
O'Brien, E;Pickering, T;Gerin, W
通讯作者：
Gerin, W
影响因子：
--
作者：
Little, P;Barnett, J;Mant, D
通讯作者：
Mant, D