Colonization of second-trimester placenta parenchyma
Colonization of second-trimester placenta parenchyma
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DOI：
10.1016/j.ajog.2007.11.068
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发表时间：
2008-07-01
影响因子：
9.8
通讯作者：
Leviton, Alan
中科院分区：
文献类型：
--
作者：
Onderdonk, Andrew B.;Hecht, Jonathan L.;Leviton, Alan
目的：明显健康的非妊娠子宫内存在细菌、支原体和脲原体。殖民化的程度仍然难以捉摸，孤立的微生物，早产和胎儿inflammation.STUDY设计之间的关系：绒毛膜实质活检标本从1083胎盘前交付的第28周的妊娠开始进行了培养，胎盘进行了组织学检查。个别微生物和微生物组的频率进行了评估，导致早产，分娩途径，胎龄，胎盘morphology.RESULTS：胎盘剖宫产与先兆子痫的过程中的层有最低的细菌回收率（25%）。早产率最高，随着胎龄的增加而下降，从23周的79%下降到27周的43%。胎盘实质中微生物的存在与绒毛膜胎儿干血管或脐带血管中中性粒细胞的存在有关。结论：高定植率似乎与早产和胎龄相关的现象相一致。胎盘实质内微生物的存在具有重要的生物学意义。
OBJECTIVE: The overtly healthy, nonpregnant uterus harbors bacteria, Mycoplasma and Ureaplasma. The extent of colonization remains elusive, as are relationships between isolated microorganisms, preterm labor and fetal inflammation.STUDY DESIGN: Biopsy specimens of chorion parenchyma from 1083 placentas delivered before the beginning of the 28th week of gestation were cultured, and the placentas were examined histologically. The frequencies of individual microorganisms and groups of microorganisms were evaluated in strata of processes leading to preterm delivery, routes of delivery, gestational age, and placenta morphology.RESULTS: Placentas delivered by cesarean section with preeclampsia had the lowest bacterial recovery rate (25%). Preterm labor had the highest rates, which decreased with increasing gestational age from 79% at 23 weeks to 43% at 27 weeks. The presence of microorganisms in placenta parenchyma was associated with the presence of neutrophils in the fetal stem vessels of the chorion or in the vessels of the umbilical cord.CONCLUSION: The high rate of colonization appears to coincide with phenomena associated with preterm delivery and gestational age. The presence of microorganisms within placenta parenchyma is biologically important.