Natural selection drives Drosophila immune system evolution.
Natural selection drives Drosophila immune system evolution.
复制标题
自然选择驱动果蝇免疫系统的进化。
DOI：
10.1093/genetics/164.4.1471
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发表时间：
2003
期刊：
影响因子：
3.3
通讯作者：
Begun,DavidJ
中科院分区：
文献类型：
--
作者：
Schlenke,ToddA;Begun,DavidJ
来自不同来源的证据表明，自然选择可能经常在宿主免疫系统蛋白质的进化中发挥作用。然而，很少有人试图在分析单个物种的几个免疫系统相关基因的基础上进行一般群体遗传推断。在这里，我们提出的DNA多态性和分歧的数据，从34个基因被认为是在先天免疫系统ofDrosophila simulans的功能，并比较这些数据从28个非免疫基因测序相同的线。一些统计数据，包括平均KA/KS比率，平均沉默杂合性，平均单倍型多样性，免疫和非免疫基因之间的显着差异，表明定向选择在免疫系统蛋白质进化中的重要作用。与哺乳动物免疫球蛋白和其他蛋白质的数据相反，我们没有发现果蝇免疫系统蛋白质选择性维持蛋白质多样性的有力证据。这可能是果蝇普遍的先天免疫反应的结果。
Evidence from disparate sources suggests that natural selection may often play a role in the evolution of host immune system proteins. However, there have been few attempts to make general population genetic inferences on the basis of analysis of several immune-system-related genes from a single species. Here we present DNA polymorphism and divergence data from 34 genes thought to function in the innate immune system ofDrosophila simulansand compare these data to those from 28 nonimmunity genes sequenced from the same lines. Several statistics, including averageKA/KSratio, average silent heterozygosity, and average haplotype diversity, significantly differ between the immunity and nonimmunity genes, suggesting an important role for directional selection in immune system protein evolution. In contrast to data from mammalian immunoglobulins and other proteins, we find no strong evidence for the selective maintenance of protein diversity in Drosophila immune system proteins. This may be a consequence of Drosophila’s generalized innate immune response.