Relaxin is essential for renal vasodilation during pregnancy in conscious rats
Relaxin is essential for renal vasodilation during pregnancy in conscious rats
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DOI：
10.1172/jci11975
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发表时间：
2001-06-01
影响因子：
15.9
通讯作者：
Conrad, KP
中科院分区：
文献类型：
--
作者：
Novak, J;Danielson, LA;Conrad, KP
肾脏和其他非生殖器官的显著血管扩张是怀孕期间最早发生的母体适应之一。尽管人们认识到这一非凡的生理学已经有40多年了，但与之相关的妊娠激素仍然难以捉摸。在这里，我们展示了松弛蛋白的关键作用，它是胰岛素样生长因子家族的成员，由人类和啮齿动物的黄体分泌。利用妊娠啮齿动物模型，我们使用两种方法从循环中消除松弛蛋白或其生物活性：卵巢切除和给予中和抗体。这两种药物均可消除妊娠时肾脏灌注量和肾小球滤过的升高，并可防止分离的小肾动脉肌源性反应性降低。另一种妊娠适应变化--渗透调节变化--也被废除。我们的结果表明，松弛素介导孕时的肾血管扩张反应，因此可能对母婴健康很重要。他们还增加了松弛素在妊娠的其他心血管变化中发挥作用的可能性，他们建议，像雌激素一样，松弛素应该被认为是心血管功能的调节剂。
Marked vasodilation in the kidney and other nonreproductive organs is one of the earliest maternal adaptations to occur during pregnancy. Despite the recognition of this extraordinary physiology for over four decades, the gestational hormone responsible has remained elusive. Here we demonstrate a key role for relaxin, a member of the IGF family that is secreted by the corpus luteum in humans and rodents. Using a gravid rodent model, we employ two approaches to eliminate relaxin or its biological activity from the circulation: ovariectomy and administration of neutralizing antibodies. Both abrogate the gestational elevation in renal perfusion and glomerular filtration, as well as preventing the reduction in myogenic reactivity of isolated, small renal arteries. Osmoregulatory changes, another pregnancy adaptation, are also abolished. Our results indicate that relaxin mediates the renal vasodilatory responses to pregnancy and thus may be important for maternal and fetal health. They also raise the likelihood of a role for relaxin in other cardiovascular changes of pregnancy, and they suggest that, like estrogen, relaxin should be considered a regulator of cardiovascular function.