Decomposing Parietal Memory Reactivation to Predict Consequences of Remembering
Decomposing Parietal Memory Reactivation to Predict Consequences of Remembering
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DOI：
10.1093/cercor/bhy200
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发表时间：
2019-08-01
期刊：
影响因子：
3.7
通讯作者：
Kuhl, Brice A.
中科院分区：
文献类型：
--
作者：
Lee, Hongmi;Samide, Rosalie;Kuhl, Brice A.
记忆检索可以强化记忆，但也会扭曲记忆。顶叶皮层是参与检索引起的记忆变化的候选区域，因为它反映检索成功并代表检索的内容。在这里，我们进行了一项功能磁共振成像实验，以测试不同形式的顶叶重新激活是否可以预测不同的检索结果。受试者研究单词与面孔、场景或物体的图片之间的关联，然后重复检索一半的图片，报告检索到的图片的生动性（“检索练习”）。第二天，受试者完成了对单张图片的识别记忆测试。至关重要的是，测试中使用的诱饵与所研究的图片高度相似。在行为上，检索练习增加了类似诱饵的命中率和误报率，证实了检索对后续记忆的因果影响。使用模式相似性分析，我们测量了检索实践中两种不同级别的重新激活：通用的“类别级”重新激活和特殊的“项目级”重新激活。检索练习过程中的生动记忆与顶叶皮层更强的类别和项目级重新激活有关。然而，这些措施对随后的识别记忆性能的预测存在差异：较高类别级别的重新激活倾向于预测 FA 来诱饵，而项目级别的重新激活则预测正确的拒绝。这些发现表明，顶叶重新激活可以被分解，以区分记忆检索的不同后果。
Memory retrieval can strengthen, but also distort memories. Parietal cortex is a candidate region involved in retrieval-induced memory changes as it reflects retrieval success and represents retrieved content. Here, we conducted an fMRI experiment to test whether different forms of parietal reactivation predict distinct consequences of retrieval. Subjects studied associations between words and pictures of faces, scenes, or objects, and then repeatedly retrieved half of the pictures, reporting the vividness of the retrieved pictures ("retrieval practice"). On the following day, subjects completed a recognition memory test for individual pictures. Critically, the test included lures highly similar to studied pictures. Behaviorally, retrieval practice increased both hit and false alarm (FA) rates to similar lures, confirming a causal influence of retrieval on subsequent memory. Using pattern similarity analyses, we measured two different levels of reactivation during retrieval practice: generic "category-level" reactivation and idiosyncratic "item-level" reactivation. Vivid remembering during retrieval practice was associated with stronger category-and item-level reactivation in parietal cortex. However, these measures differentially predicted subsequent recognition memory performance: whereas higher category-level reactivation tended to predict FAs to lures, item-level reactivation predicted correct rejections. These findings indicate that parietal reactivation can be decomposed to tease apart distinct consequences of memory retrieval.