Serum cytokine levels in Kleine-Levin syndrome.
Serum cytokine levels in Kleine-Levin syndrome.
复制标题
克莱恩-莱文综合征的血清细胞因子水平。
DOI：
10.1016/j.sleep.2015.02.540
复制
发表时间：
2015
期刊：
影响因子：
4.8
通讯作者：
Mignot,Emmanuel
中科院分区：
文献类型：
--
作者：
Kornum,BirgitteRahbek;Rico,Thomas;Lin,Ling;Huang,Yu-Shu;Arnulf,Isabelle;Jennum,Poul;Mignot,Emmanuel
Kleine-Levin综合征（KLS）是一种罕见的睡眠障碍，可引起反复发作的严重睡眠过度、认知障碍、冷漠和现实感丧失。这些事件穿插着长时间的正常睡眠，认知和行为。KLS的发病机制尚不清楚。本研究的目的是确定血清细胞因子水平与KLS患者期间和之间epission.Patients/MethodsFifty-two典型KLS患者包括在研究中，其中17例患者捐赠的血液样本期间和之间的事件。在美国、法国和中国台湾的临床环境中采集血样。样本的处理进行在斯坦福大学中心睡眠科学和Medicine.ResultsWe没有观察到任何变化，血清细胞因子水平在KLS事件之间的事件相比。在一个小队列的无症状KLS患者和年龄和性别匹配的健康对照组（n = 8/组），其血液样本都收集和处理在同一天;无症状KLS患者血清sVCAM 1细胞因子的水平显着高于健康controls.ConclusionThese数据表明，KLS发作不伴有异常的全身免疫反应。
ObjectiveKleine–Levin Syndrome (KLS) is a rare sleep disorder causing recurrent symptomatic episodes of severe hypersomnia, cognitive impairment, apathy, and derealization. These episodes are interspersed with long periods of normal sleep, cognition, and behavior. The pathogenesis of KLS is still unknown. The objective of this study was to determine serum cytokine levels in patients with KLS during and between episodes.Patients/MethodsFifty-two typical KLS patients were included in the study of whom 17 patients donated blood samples both during and between episodes. Blood samples were collected in USA, France, and Taiwan in a clinical setting. Processing of the samples was performed at the Stanford Center for Sleep Sciences and Medicine.ResultsWe did not observe any changes in serum cytokine levels during KLS episodes compared to between episodes. In a small cohort of asymptomatic KLS patients and age- and gender matched healthy controls (n = 8/group) whose blood samples were all collected and processed at the same day; asymptomatic KLS patients had significantly higher levels of serum sVCAM1 cytokine compared to healthy controls.ConclusionThese data suggest that KLS episodes are not accompanied by an abnormal systemic immune reaction.