Childhood growth and breast cancer
Childhood growth and breast cancer
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DOI：
10.1093/aje/kwh097
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发表时间：
2004-04-01
影响因子：
5
通讯作者：
Wadsworth, MEJ
中科院分区：
文献类型：
--
作者：
De Stavola, BL;Silva, ID;Wadsworth, MEJ
成年人身高与乳腺癌风险呈正相关。这种关联的机制很复杂，因为成年身高与初潮年龄正相关，而初潮年龄又与乳腺癌风险负相关。作者使用了一个英国队列的2,547名女孩的前瞻性数据，从1946年出生到1999年底，研究了乳腺癌风险与儿童生长的关系。正如预期的那样，成年身高与初潮年龄和乳腺癌呈正相关。在儿童时期，平均而言，病例比非病例更高更瘦。在包含所有生长成分的模型中，乳腺癌风险的重要预测因子是4-7岁时的身高增长速度（对于一个标准差增加，比值比（OR）= 1.54，95%置信区间（CI）：1.13，2.09）和年龄11-15岁（OR = 1.29，95% CI：0.97，1.71）和2-4岁体重指数速度（体重（kg）/身高（m2）/年）（OR = 0.63，95% CI：0.48，0.83）。这些变量的影响在初潮早的女性（年龄
Adult height is known to be positively associated with breast cancer risk. The mechanism underlying this association is complex, since adult height is positively correlated with age at menarche, which in turn is negatively associated with breast cancer risk. The authors used prospective data from a British cohort of 2,547 girls followed from birth in 1946 to the end of 1999 to examine breast cancer risk in relation to childhood growth. As expected, adult height was positively associated with age at menarche and breast cancer. In childhood, cases were taller and leaner, on average, than noncases. Significant predictors of breast cancer risk in models containing all components of growth were height velocity at age 4-7 years (for a one-standard-deviation increase, odds ratio (OR) = 1.54, 95% confidence interval (CI): 1.13, 2.09) and age 11-15 years (OR = 1.29, 95% CI: 0.97, 1.71) and body mass index velocity (weight (kg)/height (m)(2)/year) at age 2-4 years (OR = 0.63, 95% CI: 0.48, 0.83). The effects of these variables were particularly marked in women with early menarche (age