EXPERIMENTAL ENDOCARDITIS DUE TO PSEUDOMONAS-AERUGINOSA .2. THERAPY WITH CARBENICILLIN AND GENTAMICIN
EXPERIMENTAL ENDOCARDITIS DUE TO PSEUDOMONAS-AERUGINOSA .2. THERAPY WITH CARBENICILLIN AND GENTAMICIN
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DOI：
10.1093/infdis/136.3.327
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发表时间：
1977-01-01
影响因子：
6.4
通讯作者：
FEKETY, FR
中科院分区：
文献类型：
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作者：
ARCHER, G;FEKETY, FR
用高剂量（7.5 mg/kg）庆大霉素治疗6 d，低剂量（5 mg/kg）庆大霉素治疗6 d或2 wk，羧苄青霉素（400 mg/kg）治疗6 d或2 wk，或低剂量庆大霉素和羧苄青霉素（400 mg/kg）联合治疗6 d或2 wk。给予高剂量庆大霉素6天（44%与灭菌赘生物）或联合治疗14天（64%）的家兔比单独给予低剂量庆大霉素或羧苄青霉素2周（分别为23.5%和无）的家兔更有效地完成心脏赘生物灭菌。联合治疗2周可预防治疗后随访的所有6只治疗家兔的复发;治疗2周后，所有4只羧苄青霉素治疗动物和4/6只低剂量庆大霉素治疗动物复发。9只家兔单独给予庆大霉素2 wk后，有4只血清肌酐升高。治疗成功与协同抗生素组合相关，血清中的峰值杀菌滴度为1：16和高浓度的庆大霉素。
Rabbits with left-sided endocarditis due to P. aeruginosa were treated with a high dose (7.5 mg/kg) of gentamicin for 6 days, a low dose (5 mg/kg) of gentamicin for 6 days or 2 wk, carbenicillin (400 mg/kg) for 6 days or 2 wk or a combination of the lower dose of gentamicin and carbenicillin (400 mg/kg) for 6 days or 2 wk. Sterilization of cardiac vegetation was accomplished more effectively in rabbits given the higher dose of gentamicin for 6 days (44% with sterilized vegetation) or combination therapy for 14 days (64%) than in rabbits given the lower dose of gentamicin or carbenicillin alone for 2 wk (23.5% and none, respectively). Combination therapy for 2 wk prevented relapse in all of 6 treated rabbits that were followed after treatment; all 4 animals treated with carbenicillin and 4 of 6 animals treated with the lower dose of gentamicin relapsed after 2 wk of treatment. Levels of creatinine in serum were elevated in 4 of 9 rabbits that received gentamicin alone for 2 wk. Therapeutic success was associated with a synergistic antibiotic combination, a peak bactericidal titer in serum of .gtoreq. 1:16 and a high level of gentamicin in serum.