A protein-protein docking benchmark

A protein-protein docking benchmark
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DOI:
10.1002/prot.10390
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发表时间:
2003-07-01
期刊:
PROTEINS-STRUCTURE FUNCTION AND GENETICS
影响因子:
--
通讯作者:
Weng, ZP
Weng, ZP
中科院分区:
其他
文献类型:
--
作者:
Chen, R;Mintseris, J;Weng, ZP

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我们已经开发了一种用于测试蛋白质蛋白对接算法的非冗余基准。目前,它包含59例测试用例:22个酶抑制剂复合物,19种抗体 - 抗原复合物,其他11个复合物和7个困难的测试用例。三十一个测试案例,即受体和配体的未结构结构可用,如下所示:16个酶抑制剂,5种抗体 - 抗原,5个抗体 - 其他5个和5个困难。这样的集中资源不仅应作为一个大型策划测试集,而且还可以使对接社区受益,而且还可以作为比较不同算法的共同点。该基准可以在(http://zlab.bu.edu/similar torong/dock/benchmark.shtml)上获得。 (c)2003 Wiley-Liss,Inc。
We have developed a nonredundant benchmark for testing protein-protein docking algorithms. Currently it contains 59 test cases: 22 enzyme-inhibitor complexes, 19 antibody-antigen complexes, 11 other complexes, and 7 difficult test cases. Thirty-one of the test cases, for which the unbound structures of both the receptor and ligand are available, are classified as follows: 16 enzyme-inhibitor, 5 antibody-antigen, 5 others, and 5 difficult. Such a centralized resource should benefit the docking community not only as a large curated test set but also as a common ground for comparing different algorithms. The benchmark is available at (http://zlab.bu.edu/similar torong/dock/benchmark.shtml). (C) 2003 Wiley-Liss, Inc.