Electroacupuncture reduces morphine-induced emesis in ferrets: a pilot study.
Electroacupuncture reduces morphine-induced emesis in ferrets: a pilot study.
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DOI：
10.1089/acm.1995.1.257
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发表时间：
1995-01-01
期刊：
影响因子：
--
通讯作者：
Wynn, R L
中科院分区：
文献类型：
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作者：
Lao, L;Wong, R H;Wynn, R L
采用1.0 Hz和5.0 Hz两种不同的刺激频率（每组5只雪貂），在雪貂内关穴（P6）进行5分钟的电针（EA）治疗吗啡诱导的呕吐。与未接受EA治疗的对照组相比，两种EA治疗均减少了呕吐次数（1.0 Hz时减少39%，p < or = 0.05； 5.0 Hz时减少43%，p < or = 0.05），并延长了呕吐发作时间。该模型表明，在这些条件下，EA是一种有效的止吐剂，可以进一步研究针刺和呕吐的机制。
We treated morphine-induced emesis in ferrets with electroacupuncture (EA) for five minutes at the acupuncture point Neiguan (P6) using two different frequencies of stimulation: 1.0 Hz and 5.0 Hz (n = 5 ferrets per group). Both EA treatments reduced the number of emetic episodes (39% reduction of episodes, p < or = 0.05 at 1.0 Hz; 43% reduction of episodes, p < or = 0.05 at 5.0 Hz) and prolonged the onset time of emesis as compared with control receiving no EA. This model demonstrates that under these conditions EA is effective as an antiemetic against morphine in the ferret and may allow for further studies on the mechanisms of acupuncture and emesis.