Epigenetic considerations of the APOE gene
Epigenetic considerations of the APOE gene
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DOI：
10.1515/bmc-2014-0039
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发表时间：
2015-03-01
影响因子：
--
通讯作者：
Foraker, Jessica
中科院分区：
文献类型：
--
作者：
Yu, Chang-En;Foraker, Jessica
载脂蛋白 E (APOE) 基因与许多生理状况密切相关，包括健康衰老、心血管健康改变和认知功能。这些联系主要通过使用 APOE 的三种常见遗传变异（epsilon 2、epsilon 3 和 epsilon 4）进行表型-基因型关联研究来建立。这些变体编码三种 apoE 蛋白亚型（E2、E3 和 E4），它们的结构略有不同，因此在脂质代谢中具有不同的功能。然而，这些亚型的不同脂质结合和转移特性不能完全解释 APOE 与如此广泛的生理表型的关联。 APOE 多效性作用的一种可能解释可能在于其独特的表观遗传特性。在本文中，我们简要回顾了 APOE 基因和蛋白质、其疾病关联和表观遗传成分，重点关注 DNA 甲基化。我们最后讨论了 APOE 在疾病中的前瞻性表观遗传影响。
The apolipoprotein E (APOE) gene is robustly linked with numerous physiological conditions, including healthy aging, altered cardiovascular fitness, and cognitive function. These connections have been established primarily by phenotype-genotype association studies using APOE's three common genetic variants (epsilon 2, epsilon 3, and epsilon 4). These variants encode for the three apoE protein isoforms (E2, E3, and E4), which have slightly different structures and, consequently, distinct functions in lipid metabolism. However, the differential lipid binding and transferring properties of these isoforms cannot fully explain the association of APOE with such a wide range of physiological phenotypes. One potential explanation for APOE's pleiotropic roles may lie in its unique epigenetic properties. In this article, we present a brief review of the APOE gene and protein, its disease associations, and epigenetic components, with a focus on DNA methylation. We close with a discussion of the prospective epigenetic implications of APOE in disease.