Changes in CT angiographic opacification of porcine coronary artery wall with patchy altered flow in vasa vasorum.
Changes in CT angiographic opacification of porcine coronary artery wall with patchy altered flow in vasa vasorum.
复制标题
猪冠状动脉壁 CT 血管造影混浊变化，血管滋养管血流斑片状改变。
DOI：
10.1007/s10554-013-0198-6
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发表时间：
2013
期刊：
影响因子：
--
通讯作者：
Ritman,ErikL
中科院分区：
文献类型：
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作者：
Moritz,Regina;Anderson,JillL;Vercnocke,AndrewJ;Wentz,RobertJ;Ritman,ErikL
评估全身CT在检测冠状动脉壁局部血管增强或减弱的潜力。我们使用微球栓塞冠状动脉血管，在动脉壁周围产生小区域的低灌注和高灌注，以及饮食引起的高胆固醇血症。作为局部血管生成的刺激，如发生在冠状动脉壁斑块形成的早期，微球被选择性地注射到麻醉猪的LAD冠状动脉管腔中。随后，14头猪（急性）在注射造影剂期间收获一段LAD，并快速冷冻，用于随后的低温静态微ct。另外13头猪（慢性）被允许恢复，喂养高胆固醇饮食，3个月后再次麻醉，切除一段前冠状动脉并进行扫描。在与管腔轴成直角的连续微ct图像上测量造影剂在动脉壁内的空间分布，每个横截面图像的壁面积约为（0.1 mm）3in。在急性动物中，动脉壁灌注不足的栓塞灌注区域周围没有局部增强的造影剂区域，但在慢性动物中，灌注不足的区域周围有增强的造影剂。这些结果表明，CT可能能够检测到动脉壁血管增加的局部区域，作为早期动脉粥样硬化刺激血管增生的指标。
To evaluate the potential of whole-body CT to detect localized areas of decreased or increased vascularity in coronary arterial walls. We used both microsphere embolization of coronary artery vasa vasorum to generate small areas of hypoperfusion and surrounding hyperperfusion of the arterial wall and diet-induced hypercholesterolemia. As a stimulus for localized angiogenesis, such as occurs in early plaque formation in the coronary arterial wall, microspheres were injected selectively into the LAD coronary artery lumens of anesthetized pigs. Fourteen pigs (acute) then had a segment of their LAD harvested during injection of contrast medium and snap-frozen for subsequent cryo-static micro-CT. An additional thirteen pigs (chronic) were allowed to recover, fed a high cholesterol diet and 3 months later were again anesthetized and a segment of the LAD artery harvested and scanned. The spatial distribution of the contrast agent within the arterial wall was measured in contiguous micro-CT images at right angles to the lumen axis with the area of wall in each cross-sectional image being approximately (0.1 mm)3in size. In the acute animals there were no localized areas of increased contrast around the hypoperfused embolized perfusion territories in the arterial wall, but in the chronic animals the hypoperfused areas were surrounded by increased contrast. These results suggest that CT might be able to detect localized regions of increased vascularity in the arterial wall as an indicator of early atherosclerotic stimulation of vasa vasorum proliferation.