Adhesive recognition sequences.
Adhesive recognition sequences.
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DOI：
10.1016/s0021-9258(18)98761-2
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发表时间：
1991-07
期刊：
影响因子：
--
通讯作者：
Kenneth M. Yamada
中科院分区：
文献类型：
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作者：
Kenneth M. Yamada
特异性细胞粘附和细胞迁移是胚胎发育、肿瘤细胞转移和伤口愈合中反复出现的主题。我们对细胞粘附和迁移与细胞外基质分子相互作用的分子基础的理解的最新进展已经集中在许多细胞相互作用依赖于特异性粘附识别序列的概念上（在参考文献中综述）。第1-8段）。如下文将详细描述的，粘附蛋白中的某些短肽序列被认为是特异性质膜受体识别和结合的位点（表I）。许多特异性细胞表面受体，特别是整合素，通过识别每种蛋白中不同的特异性肽序列来介导细胞与纤连蛋白、层粘连蛋白或胶原蛋白的粘附（图1）。此外，一些受体可以识别几种不同蛋白质中的相同特异性序列（1-5，8）。相反，单个粘附蛋白可以包含由不同受体识别的几个不同序列（1-8）。如此多的结合活性的潜在组合的存在为单个细胞可能的相互作用库提供了相当大的复杂性。
Specific cellular adhesion and migration of cells are recurring themes in embryonic development, tumor cell metastasis, and wound healing. Recent advances in our understanding of the molecular basis of cell adhesive and migratory interactions with extracellular matrix molecules have converged on the concept that many cell interactions are dependent on specific adhesive recognition sequences (reviewed in Refs. 1-8). As will be described in detail below, certain short peptide sequences in adhesion proteins are thought to serve as sites for recognition and binding by specific plasma membrane receptors (Table I). A number of specific cell surface receptors, particularly integrins, mediate the adhesion of cells to fibronectin, laminin, or collagen by recognizing different, specific peptide sequences in each (Fig. 1). Moreover, some receptors can recognize the same specific sequence in several different proteins (1-5, 8). Conversely, a single adhesion protein can contain several different sequences that are recognized by distinct receptors (1-8). The existence of so many potential combinations of binding activities provides considerable complexity to the repertoire of interactions possible for an individual cell.