In vivo Raman study of the living rat esophagus and stomach using a micro-Raman probe under an endoscope
In vivo Raman study of the living rat esophagus and stomach using a micro-Raman probe under an endoscope
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DOI：
10.1366/000370207781269747
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发表时间：
2007-06-01
影响因子：
3.5
通讯作者：
Sato, Hidetoshi
中科院分区：
文献类型：
--
作者：
Hattori, Yusuke;Komachi, Yuichi;Sato, Hidetoshi
研制了一种用于活体大鼠拉曼光谱测量的微型拉曼探针内窥镜系统。测量在麻醉和人工呼吸下进行，以尽量减少对大鼠的影响。成功地测量了活体大鼠食管和胃的拉曼光谱。我们的研究结果表明，拉曼光谱反映了在内窥镜图像中无法区分的亚表面组织结构。实验结束后，大鼠恢复正常，没有任何后遗症。实验结果表明，该系统对大鼠的拉曼光谱测量是安全、无创的。
A small endoscope system equipped with a micro Raman probe is developed for in vivo Raman measurements in living rats. The measurements are done under anesthesia and artificial respiration to minimize the impact on the rats. Raman spectra of living rat esophagus and stomach are successfully measured. Our results suggest that the Raman spectra reflect subsurface tissue structure that cannot be distinguished in the endoscope image. After the experiments, rats recover without any aftereffects. It is verified that the Raman measurement using the present system is safe and noninvasive for rats.