Changes of blood lactate levels after repetitive transcranial magnetic stimulation
Changes of blood lactate levels after repetitive transcranial magnetic stimulation
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DOI：
10.1016/j.neulet.2008.11.064
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发表时间：
2009-01-30
影响因子：
2.5
通讯作者：
Perciavalle, Vincenzo
中科院分区：
文献类型：
--
作者：
Alagona, Giovanna;Coco, Marinella;Perciavalle, Vincenzo
目的是研究是否重复经颅磁刺激（rTMS）的运动皮层可以诱导修改外周血乳酸值。研究纳入了19名年轻健康志愿者;在研究期间，所有受试者都坐在舒适的扶手椅上休息。通过连续肌电记录评估肌肉激活。经颅磁刺激通过在颅顶使用圆形线圈进行。静息运动阈值（rMT）定义为在20个连续刺激中的约50%中能够在放松的对侧目标肌肉中诱导幅度> 50 μ V的运动反应的最低TMS强度。在单次低频（1 Hz持续15 min）rTMS（LF rTMS）或高频（20 Hz持续15 min）rTMS（HF rTMS）之前、之后即刻和之后10 min测量静脉血乳酸值。果然低频rTMS引起运动皮层兴奋性降低，而高频rTMS引起运动皮层兴奋性增加。然而，在本研究中，我们观察到这两种情况都与血乳酸的显着增加有关。由于在我们的实验条件下，我们可以排除肌肉产生的乳酸，外周血乳酸值的显着增加，观察到10分钟后结束的rTMS会议，可能是由于通过血脑屏障的脑产生的乳酸的交叉。(C)2008爱思唯尔爱尔兰有限公司保留所有权利。
The objective was to study whether repetitive transcranial magnetic stimulation (rTMS) of the motor cortex could induce modification of peripheral blood lactate values. Nineteen young healthy volunteers were included; during the study, all subjects were at rest, sitting on a comfortable armchair. The muscular activation was evaluated by continuous electromyographic record. TMS was performed by using a circular coil at the vertex. Resting motor threshold (rMT) was defined as the lowest TMS intensity able to induce motor responses of an amplitude > 50 mu V in the relaxed contralateral target muscle in approximately 50% of 20 consecutive stimuli. Venous blood lactate values were measured before, immediately after and 10 min after a single session of low frequencies (1 Hz for 15 min) rTMS (LF rTMS) or high frequency (20 Hz for 15 min) rTMS (HF rTMS). As expected. LF rTMS induced a decrease of motor cortex excitability, whereas HF rTMS evoked an increase of motor cortex excitability. However, in the present investigation we observed that both conditions are associated to a significant increase of blood lactate. Since in our experimental conditions we can exclude a muscular production of lactate, the significant increment of peripheral blood lactate values, observed 10 min after the end of the rTMS session, is probably due to the crossing by brain-produced lactate of the blood-brain barrier. (C) 2008 Elsevier Ireland Ltd. All rights reserved.