Vitamin E levels, cognitive impairment and dementia in older persons: the InCHIANTI study
Vitamin E levels, cognitive impairment and dementia in older persons: the InCHIANTI study
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DOI：
10.1016/j.neurobiolaging.2004.09.002
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发表时间：
2005-07-01
影响因子：
4.2
通讯作者：
Ferrucci, L
中科院分区：
文献类型：
--
作者：
Cherubini, A;Martin, A;Ferrucci, L
有相互矛盾的证据表明，抗氧化剂有助于维持老年人的认知功能。我们在意大利进行的一项基于人群的队列研究中调查了维生素E血浆水平是否与痴呆和认知障碍的存在有关。共有1033名年龄在65岁以上的参与者接受了临床和神经心理学检查，献血进行维生素E分析，并评估了他们的饮食。血浆维生素E水平在最低三分位数的参与者患痴呆症的概率明显更高（OR 2.6，95% CI 1.0 - 7.1），并且患有认知障碍（OR 2.2，95% CI 1.2 - 4.2）与调整年龄、性别、教育、血脂水平、能量摄入、维生素E摄入后维生素E最高三分位数的人群相比，和吸烟。这项研究支持了这样一种观点，即较高的维生素E血浆水平可能对老年受试者的认知障碍和痴呆症提供显着的保护。(c)2004年爱思唯尔公司All rights reserved.
There is conflicting evidence that antioxidants contribute to maintaining cognitive function in elderly subjects. We investigated whether vitamin E plasma levels are related to the presence of dementia and cognitive impairment in a population-based cohort study conducted in Italy. A total of 1033 participants aged at least 65 years received clinical and neuropsychological examinations, donated blood for vitamin E analysis and had their diets assessed. Participants with plasma vitamin E levels in the bottom tertile had a significantly higher probability of being demented (OR 2.6, 95% CI 1.0-7.1) and also of suffering from cognitive impairment (OR 2.2, 95% CI 1.2-4.2) compared to those in the highest vitamin E tertile after adjustment for age, gender, education, lipid levels, energy intake, vitamin E intake, and smoking. This study supports the notion that higher vitamin E plasma levels might provide significant protection against cognitive impairment and dementia in elderly subjects. (c) 2004 Elsevier Inc. All rights reserved.