Association of Composite IS26-sul3 Elements with Highly Transmissible IncI1 Plasmids in Extended-Spectrum-β-Lactamase-Producing Escherichia coli Clones from Humans
Association of Composite IS26-sul3 Elements with Highly Transmissible IncI1 Plasmids in Extended-Spectrum-β-Lactamase-Producing Escherichia coli Clones from Humans
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DOI：
10.1128/aac.01448-10
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发表时间：
2011-05-01
影响因子：
4.9
通讯作者：
Coque, Teresa M.
中科院分区：
文献类型：
--
作者：
Curiao, Tania;Canton, Rafael;Coque, Teresa M.
报告了IS 440-sul 3平台与编码超广谱β-内酰胺酶（ESBLs;主要是SHV-12和CTX-M-14）的IncI 1质粒携带的Tn 21 1 1类整合子在全世界大肠埃希菌A（ST 10、ST 23和ST 46）、B1（ST 155、ST 351和ST 359）和D/B2（ST 131）群克隆中的相关性。在计算机上比较分析的sul 3元件在GenBank数据库中显示的进化sul 3平台托管不同的转座元件促进IS 26复合转座子的潜在起源和进一步的插入元件介导的促进安排。
The association of an IS440-sul3 platform with Tn21 class 1 integrons carried by IncI1 plasmids encoding extended-spectrum beta-lactamases (ESBLs; mainly SHV-12 and CTX-M-14) among worldwide Escherichia coli clones of phylogroups A (ST10, ST23, and ST46), B1 (ST155, ST351, and ST359), and D/B2 (ST131) is reported. An in silico comparative analysis of sul3 elements available in the GenBank database shows the evolution of sul3 platforms by hosting different transposable elements facilitating the potential genesis of IS26 composite transposons and further insertion element-mediated promoted arrangements.