Spectral-Domain Optical Coherence Tomography as a Potential Biomarker in Huntington's Disease
Spectral-Domain Optical Coherence Tomography as a Potential Biomarker in Huntington's Disease
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DOI：
10.1002/mds.26486
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发表时间：
2016-03-01
影响因子：
8.6
通讯作者：
Garrett, Carolina
中科院分区：
文献类型：
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作者：
Andrade, Carlos;Beato, Joao;Garrett, Carolina
背景光谱域光学相干断层扫描已被用于几种神经系统疾病，并已提出视乳头周围和黄斑测量作为这些疾病的潜在生物标志物。本研究的目的是调查视网膜和脉络膜的变化，在亨廷顿病，并评估任何潜在的相关性与阶段的diseases.MethodsA横断面观察研究比较患者与亨廷顿病和控制。采用统一的亨廷顿病评定量表对患者进行评估。光谱域光学相干断层扫描与增强深度成像，乳头周围脉络膜和视网膜神经纤维层厚度和黄斑视网膜和脉络膜厚度进行了evaluated.Results15眼8例患者和16眼8性别，年龄，平均屈光不正匹配的健康对照组。平均（231.352.8 vs 296.2 +/- 57.1，P=0.033），中心（341.8 +/- 70.5 vs 252.0 +/- 57.9，P=0.015）和劣效性（225.3 +/- 57.9 vs 313.8 +/- 55.2，P=0.007）与对照组相比，患者黄斑脉络膜厚度显著降低。在黄斑视网膜或视乳头周围视网膜和脉络膜测量中没有观察到差异。然而，统一亨廷顿氏病评定量表的总运动评分与平均（r（2）=0.585，P=0.027）、上级（r（2）=0.653，P=0.015）、鼻音（r（2）=0.642，P=0.017）和下音（r（2）=0.574，P =0.017）呈负相关。P=0.029）macular retinal thickness.ConclusionsOur结果表明，脉络膜和视网膜黄斑改变亨廷顿病，并可能成为有用的生物标志物，用于监测神经变性在这种疾病。脉络膜的受累也可能支持最近发现的亨廷顿病血管受累。(c)2016运动障碍协会
BackgroundSpectral-domain optical coherence tomography has been used in several neurological conditions, and peripapillary and macular measurements have been proposed as potential biomarkers in these disorders. The aim of this study was to investigate retinal and choroidal changes in Huntington's disease and to evaluate any potential correlation with the stage of the disease.MethodsA cross-sectional observational study compared patients with Huntington's disease and controls. Patients were evaluated using the Unified Huntington's Disease Rating Scale. Spectral-domain optical coherence tomography with enhanced depth imaging was used, and peripapillary choroidal and retinal nerve fiber layer thickness and macular retinal and choroidal thickness were evaluated.ResultsFifteen eyes of 8 patients and 16 eyes of 8 sex-, age-, and mean refractive error-matched healthy controls were included. Average (231.352.8 vs 296.2 +/- 57.1, P=0.033), central (341.8 +/- 70.5 vs 252.0 +/- 57.9, P=0.015), and inferior (225.3 +/- 57.9 vs 313.8 +/- 55.2, P=0.007) macular choroidal thickness were significantly reduced in patients, in comparison with controls. No differences were observed in macular retina or peripapillary retinal and choroidal measurements. However, there was a negative correlation between Total Motor Score of the Unified Huntington's Disease Rating Scale and average (r(2)=0.585, P=0.027), superior (r(2)=0.653, P=0.015), nasal (r(2)=0.642, P=0.017), and inferior (r(2)=0.574, P=0.029) macular retinal thickness.ConclusionsOur results suggest that both the choroidal and retinal macula are altered in Huntington's disease and may become useful biomarkers for monitoring neurodegeneration in this disease. The involvement of the choroid may also support the recent findings of vascular involvement in Huntington's disease. (c) 2016 Movement Disorder Society