Synthesis of Substituted Anilines from Cyclohexanones Using Pd/C-Ethylene System and Its Applocation to Indole Synthesis
Synthesis of Substituted Anilines from Cyclohexanones Using Pd/C-Ethylene System and Its Applocation to Indole Synthesis
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Pd/C-乙烯体系环己酮合成取代苯胺及其在吲哚合成中的应用
DOI：
10.1021/acs.orglett.0c04056
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发表时间：
2021
期刊：
影响因子：
5.2
通讯作者：
Masahiko Hayashi
中科院分区：
文献类型：
--
作者：
Katsumi Maeda;Ryosuke Matsubara;Masahiko Hayashi
报道了以环己酮为原料，用Pd/ c -乙烯体系合成苯胺和吲哚。发现在无氧条件下，NH4OAc和k2co3的简单组合最适合进行该反应。环己酮和乙烯之间的氢转移产生所需的产物。该反应耐受起始环己酮的多种取代。
The synthesis of anilines and indoles from cyclohexanones using a Pd/C–ethylene system is reported. A simple combination of NH4OAc and K2CO3undernonaerobicconditions was found to be the most suitable to perform this reaction. Hydrogen transfer between cyclohexanone and ethylene generates the desired products. The reaction tolerates a variety of substitutions on the starting cyclohexanones.