Quercetin reduces systolic blood pressure and plasma oxidised low-density lipoprotein concentrations in overweight subjects with a high-cardiovascular disease risk phenotype: a double-blinded, placebo-controlled cross-over study
Quercetin reduces systolic blood pressure and plasma oxidised low-density lipoprotein concentrations in overweight subjects with a high-cardiovascular disease risk phenotype: a double-blinded, placebo-controlled cross-over study
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DOI：
10.1017/s0007114509359127
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发表时间：
2009-10-14
影响因子：
3.6
通讯作者：
Mueller, Manfred J.
中科院分区：
文献类型：
--
作者：
Egert, Sarah;Bosy-Westphal, Anja;Mueller, Manfred J.
经常食用类黄酮可以降低CVD的风险。然而，单个类黄酮的作用，例如槲皮素，仍然不清楚。本研究旨在研究槲皮素补充剂对93名年龄在25-65岁之间的超重或肥胖受试者的血压、脂质代谢、氧化应激标志物、炎症和身体成分的影响。在一项双盲、安慰剂对照交叉试验中，受试者随机接受150 mg槲皮素/d，治疗期为6周，间隔5周洗脱期。平均空腹血浆槲皮素浓度从71 nmol/l增加到269 nmol/l（P
Regular consumption of flavonoids may reduce the risk for CVD. However, the effects of individual flavonoids, for example, quercetin, remain unclear. The present study was undertaken to examine the effects of quercetin supplementation on blood pressure, lipid metabolism, markers of oxidative stress, inflammation, and body composition in an at-risk population of ninety-three overweight or obese subjects aged 25-65 years with metabolic syndrome traits. Subjects were randomised to receive 150 mg quercetin/d in a double-blinded, placebo-controlled cross-over trial with 6-week treatment periods separated by a 5-week washout period. Mean fasting plasma quercetin concentrations increased from 71 to 269 nmol/l (P