Nanoparticles as a potential cause of pleural and interstitial lung disease.
Nanoparticles as a potential cause of pleural and interstitial lung disease.
复制标题
DOI：
10.1513/pats.200907-061rm
复制
发表时间：
2010-05-01
期刊：
影响因子：
--
通讯作者：
Bonner, James C
中科院分区：
文献类型：
--
作者：
Bonner, James C
纳米技术有望彻底改变我们的社会，带来众多有益的创新，以改善结构材料、电子、能源、医学成像和药物输送等应用。然而，纳米材料存在潜在的安全问题，并且越来越多的证据表明纳米颗粒可能对肺和其他器官系统产生不利影响。本文将概述工程纳米颗粒和纳米技术对呼吸系统的潜在风险，并重点介绍与吸入纳米颗粒的肺部和全身影响相关的最新发现。将特别强调碳纳米管以及这些纳米颗粒可能代表环境和职业性肺部疾病的新风险的可能性，特别是对于患有哮喘等呼吸道疾病的个体。
Nanotechnology holds the promise of revolutionizing our society, bringing numerous beneficial innovations to improve structural materials, electronics, energy, medical imaging, and drug delivery, among other applications. However, nanomaterials present potential safety concerns, and there is accumulating evidence to suggest that nanoparticles may exert adverse effects on the lung and other organ systems. This article will overview the potential risks of engineered nanoparticles and nanotechnology on the respiratory system and highlight recent findings related to pulmonary and systemic effects of inhaled nanoparticles. Special emphasis will be given to carbon nanotubes and the possibility that these nanoparticles could represent an emerging risk for environmental and occupational lung disease, especially in individuals with pre-existing respiratory diseases such as asthma.