HARDI based pattern classifiers for the identification of white matter pathologies.
HARDI based pattern classifiers for the identification of white matter pathologies.
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基于 HARDI 的模式分类器，用于识别白质病理。
DOI：
10.1007/978-3-642-23629-7_29
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发表时间：
2011
期刊：
影响因子：
--
通讯作者：
Verma,Ragini
中科院分区：
文献类型：
--
作者：
Bloy,Luke;Ingalhalikar,Madhura;Eavani,Harini;Roberts,TimothyPL;Schultz,RobertT;Verma,Ragini
The paper presents a method for creating abnormality classifiers from high angular resolution diffusion imaging (HARDI) data. We utilized the fiber orientation distribution (FOD) diffusion model to represent the local WM architecture of each subject. The FOD images are then spatially normalized to a common template using a non-linear registration technique. Regions of homogeneous white matter architecture (ROIs) are determined by applying a parcellation algorithm to the population average FOD image. Orientation invariant features of each ROI’s mean FOD are determined and concatenated into a feature vector to represent each subject. Principal component analysis (PCA) was used for dimensionality reduction and a linear support vector machine (SVM) classifier is trained on the PCA coefficients. The classifier assigns each test subject a probabilistic score indicating the likelihood of belonging to the patient group. The method was validated using a 5 fold validation scheme on a population containing autism spectrum disorder (ASD) patients and typically developing (TD) controls. A clear distinction between ASD patients and controls was obtained with a 77% accuracy.
