Bunazosin reduces intraocular pressure in rabbits by increasing uveoscleral outflow.
Bunazosin reduces intraocular pressure in rabbits by increasing uveoscleral outflow.
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Bunazosin 通过增加葡萄膜巩膜流出来降低兔子的眼内压。
DOI：
10.1089/jop.1998.14.217
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发表时间：
1998
期刊：
影响因子：
--
通讯作者：
Yablonski,ME
中科院分区：
文献类型：
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作者：
Zhan,GL;Toris,CB;Camras,CB;Wang,YL;Yablonski,ME
在新西兰白化病兔身上研究了盐酸布那唑嗪（一种α1肾上腺素能拮抗剂）降眼压作用的机制以及前列腺素可能的中介作用。在0.1%布那唑嗪每日两次局部治疗的第4天，通过荧光光度计测定房水流量、流出设施和葡萄膜巩膜流出量，并通过气压计测量眼内压（IOP）。在0.1%布那唑嗪单次给药后1 - 2小时，用示踪剂输注技术测量葡萄膜巩膜流出量。在0.1%布那唑嗪单次给药前和给药后1小时，采用两水平恒压输注法测定总流出功能。评价局部应用环氧合酶抑制剂（包括0.25%吲哚美辛和0.03%氟比洛芬）对布那唑嗪后IOP降低的影响。在第七次连续给药后3小时，布那唑嗪显著（P<0.001）将IOP从基线19.6 ± 1.1 mmHg降至13.4 ± 0.8 mmHg（平均值± SEM）。吲哚美辛显著抑制一剂布那唑嗪后的IOP降低，而氟比洛芬则没有（重复测量ANOVA）。布那唑嗪显著增加葡萄膜巩膜流出量（P<0.05）和总流出量（P<0.02），但不增加荧光光度计流出量和房水流量。可以得出结论，在家兔中，0.1%布那唑嗪主要通过增加葡萄膜巩膜流出量降低IOP。在这种作用中，野牡丹素的作用是模棱两可的。
The mechanism of the ocular hypotensive effect of bunazosin hydrochloride (an α1-adrenergic antagonist) and the possible intermediary role of prostaglandins were studied in New Zealand albino rabbits. Aqueous flow, outflow facility and uveoscleral outflow were determined by fluorophotometry, and intraocular pressure (IOP) was measured by pneumatonometry on the fourth day of twice daily topical treatment with 0.1% bunazosin. Uveoscleral outflow was measured with a tracer infusion technique at 1 to 2 hours after one dose of 0.1% bunazosin. Total outflow facility was measured by a two-level constant-pressure infusion method before and at one hour after one dose of 0.1% bunazosin. The effect of topically applied cyclooxygenase inhibitors, including 0.25% indomethacin and 0.03% flurbiprofen, on the IOP reduction after bunazosin was evaluated. At 3 hours after the seventh consecutive dose given twice-daily, bunazosin significantly (P<0.001) reduced IOP to 13.4 ± 0.8 mm Hg (mean ± SEM) from a baseline of 19.6 ± 1.1 mm Hg. Indomethacin significantly inhibited the IOP reduction after one dose of bunazosin, whereas flurbiprofen did not (repeated measures ANOVA). Bunazosin significantly increased uveoscleral outflow (P<0.05) and total outflow facility (P<0.02), but not fluorophotometric outflow facility or aqueous flow. It is concluded that, in rabbits, 0.1% bunazosin reduces IOP predominantly by increasing uveoscleral outflow. The role of prostaglandins in this effect is equivocal.