THE PATHOBIOLOGY OF THE TERMINAL COMPLEMENT COMPLEXES
THE PATHOBIOLOGY OF THE TERMINAL COMPLEMENT COMPLEXES
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DOI：
10.1159/000463070
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发表时间：
1989-01-01
期刊：
影响因子：
--
通讯作者：
RAIJ, L
中科院分区：
文献类型：
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作者：
DALMASSO, AP;FALK, RJ;RAIJ, L
C5 b和其他迟效补体成分可以组装两个末端复合物（TCC）C5 b-9和SC 5 b-9。除了C5 b-9的裂解作用之外，已经证明亚裂解量的C5 b-8或C5 b-9可以刺激几种重要的细胞活性。这些作用对于解释C5 b-9在疾病实验模型中已证明的几种病理状况的产生和进展中的作用可能很重要。在特异性识别C9新抗原的抗体的帮助下，已经在人体组织中鉴定出TCC的沉积物，不仅在免疫性疾病中，而且在某些非免疫性疾病中。在后者中，已经表明TCC的沉积物与免疫球蛋白和C3的沉积物之间通常不一致。还开发了测量生物体液中SC 5 b-9的方法。发现正常血浆中SC 5 b-9水平较低。在SLE肾炎的活动期、某些感染和心肺转流期间观察到SC 5 b-9的血浆水平升高。在中枢神经系统炎性疾病患者的脑脊液和类风湿性关节炎患者的滑液中也发现了增加的水平。最近已经认识到某些患有自身免疫性疾病、感染性疾病或肿瘤性疾病的患者的血浆中针对C9新抗原的自身抗体。需要更多的工作来更好地描述这些发现对疾病活动的诊断和评估的潜在有用性。
C5b and the other late-acting complement components can assemble the two terminal complexes (TCC) C5b-9 and SC5b-9. In addition to the lytic effects of C5b-9 it has been demonstrated that sublytic amounts of C5b-8 or C5b-9 can stimulate several important cellular activities. These effects may be important to explain the role of C5b-9 in the production and progression of several pathological conditions that has been demonstrated in experimental models of disease. With the help of antibodies that specifically recognize C9 neoantigens, deposits of TCC have been identified in human tissues, not only in immunological diseases but also in certain nonimmunological diseases. In the latter it has been shown that often there is no concordance between deposits of TCC and those of immunoglobulins and C3. Methods for measuring SC5b-9 in biological fluids have also been developed. Normal plasma was found to have low levels of SC5b-9. Increased plasma levels of SC5b-9 have been observed during the active phase of SLE nephritis, in certain infections and during cardiopulmonary bypass. Increased levels were also found in the cerebrospinal fluid of patients with inflammatory diseases of the central nervous system and in the synovial fluid of patients with rheumatoid arthritis. Autoantibodies to C9 neoantigens in plasma of certain patients with autoimmune, infectious or neoplastic diseases have recently been recognized. Additional work is needed to better delineate the potential usefulness of these findings for diagnosis and evaluation of disease activity.