Bromovirus-induced remodeling of host membranes during viral RNA replication
Bromovirus-induced remodeling of host membranes during viral RNA replication
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DOI：
10.1016/j.coviro.2014.09.018
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发表时间：
2014-12-01
影响因子：
5.9
通讯作者：
Wang, Xiaofeng
中科院分区：
文献类型：
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作者：
Diaz, Arturo;Wang, Xiaofeng
雀麦花叶病毒(BMV)具有产量高、基因组小、在酵母中复制能力强等优点，已成为研究正链RNA病毒感染一般特征的有效模型。BMV RNA在外核周内质网膜上的球状、囊泡状内陷中复制，内陷通过颈状开口与细胞质保持连接。每个球体都含有病毒复制酶蛋白和基因组RNA。最近的研究表明，病毒蛋白与自身、细胞膜和宿主因子之间的多重相互作用在BMV介导的球体形成中起着至关重要的作用。这些发现可能适用于其他正链RNA病毒，并可能为抗病毒治疗提供新的靶点。
With its high yield, small genome, and ability to replicate in the yeast Saccharomyces cerevisiae, Brome mosaic virus (BMV) has served as a productive model to study the general features of positive-strand RNA virus infection. BMV RNA is replicated in spherules, vesicle-like invaginations of the outer perinuclear endoplasmic reticulum membrane that remain connected to the cytoplasm via a neck-like opening. Each spherule contains the viral replicase proteins as well as genomic RNAs. Recent advances indicate that multiple interactions between the viral proteins with themselves, cellular membranes, and host factors play crucial roles in BMV-mediated spherule formation. These findings are probably applicable to other positive-strand RNA viruses and might potentially provide new targets for antiviral treatments.