Strengthening bonds via RyR2 inhibition helps immune suppression.
Strengthening bonds via RyR2 inhibition helps immune suppression.
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通过RyR2抑制加强键有助于免疫抑制。
DOI：
10.1172/jci172986
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发表时间：
2023-12-15
影响因子：
15.9
通讯作者：
Chi, Hongbo
中科院分区：
文献类型：
--
作者：
Norton, Erienne G.;Chapman, Nicole M.;Chi, Hongbo
表达Foxp 3的T细胞因子采用多种抑制机制来减少常规T细胞（Tconv）应答并建立组织稳态。Foxp 3如何协调Treg接触依赖性抑制功能尚未完全解决。在这一期的JCI中，Wang及其同事揭示了Foxp 3介导的Ryanodine受体2（RyR 2）抑制导致强烈的Treg-DC相互作用和增强的免疫抑制。Tconvs中RyR 2的缺失表型模仿了这种作用，并在多种炎症或自身免疫性环境中为Tconvs配备了Treg样抑制功能。这项研究提供了细胞-细胞接触如何限制免疫反应性的分子和治疗见解。
Foxp3-expressing Tregs employ multiple suppressive mechanisms to curtail conventional T cell (Tconv) responses and establish tissue homeostasis. How Foxp3 coordinates Treg contact–dependent suppressive function is not fully resolved. In this issue of the JCI, Wang and colleagues revealed that Foxp3-mediated inhibition of ryanodine receptor 2 (RyR2) led to strong Treg-DC interactions and enhanced immunosuppression. RyR2 depletion in Tconvs phenocopied this effect and equipped Tconvs with Treg-like suppressive function in multiple inflammatory or autoimmune contexts. This study provides molecular and therapeutic insights underlying how cell-cell contact limits immune reactivity.
影响因子：
8
作者：
Klaus, Tanja;Wilson, Alicia S.;Vicari, Elisabeth;Hadaschik, Eva;Klein, Matthias;Helbich, Sara Salome Clara;Kamenjarin, Nadine;Hodapp, Katrin;Schunke, Jenny;Haist, Maximilian;Butsch, Florian;Probst, Hans Christian;Enk, Alexander H.;Mahnke, Karsten;Waisman, Ari;Bednarczyk, Monika;Bros, Matthias;Bopp, Tobias;Grabbe, Stephan
通讯作者：
Grabbe, Stephan