Association between urinary phthalate biomarker concentrations and adiposity among postmenopausal women.
Association between urinary phthalate biomarker concentrations and adiposity among postmenopausal women.
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DOI：
10.1016/j.envres.2023.115356
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发表时间：
2023-01
影响因子：
8.3
通讯作者：
Gabriela Vieyra;S. Hankinson;Y. Oulhote;Laura N. Vandenberg;Lesley Tinker;J. Manson;A. Shadyab;C. Thomson;Wei Bao;M. Allison;A. Odegaard;Katherine W. Reeves
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作者：
Gabriela Vieyra;S. Hankinson;Y. Oulhote;Laura N. Vandenberg;Lesley Tinker;J. Manson;A. Shadyab;C. Thomson;Wei Bao;M. Allison;A. Odegaard;Katherine W. Reeves
研究背景肥胖是慢性疾病的主要危险因素，可能与过度的腹部肥胖有关。邻苯二甲酸盐是一种环境化学物质，被认为是致肥胖剂，增加了肥胖的风险。对于邻苯二甲酸酯和肥胖之间的关联，先前的研究主要集中在体重指数上。我们假设，更精确的测量肥胖和脂肪分布可能会提供更深入的了解这些协会的作用，中心性肥胖的慢性疾病risk.ObjectivesTo评估尿邻苯二甲酸酯生物标志物和内脏和皮下脂肪组织之间的关联（增值税和SAT）在绝经后妇女登记的妇女健康倡议（WHI）。方法我们包括1125 WHI参与者可用，尿邻苯二甲酸酯生物标志物（基线，第3年）以及VAT和SAT（基线，第3年，第6年）的同步测量。通过DXA扫描估计VAT和SAT测量值。多水平混合效应模型估计在基线和增值税和SAT三年后的前瞻性关联之间的尿邻苯二甲酸酯生物标志物。ResultsIn多变量调整模型，我们观察到一些邻苯二甲酸酯生物标志物，包括邻苯二甲酸二异丁酯（DIBP）生物标志物，MCNP，和DEHP，增值税三年后的总和之间的正相关。例如，我们观察到α-DiBP和VAT浓度之间呈正相关（Q4 vs Q1 β = 7.15，95% CI -1.76-16.06; Q3 vs Q1 β = 10.94，95% CI 3.55-18.33）。相关性普遍减弱，但在对SAT进行额外调整后仍显着。MBzP与SAT呈正相关。其他邻苯二甲酸酯生物标志物的调查（MEP，MCOP，MCPP，DBP）没有显着相关的增值税或SAT。DiscussionBased上的肥胖的强大措施，这项研究提供了支持性证据，较高的尿液浓度的选择邻苯二甲酸酯化合物与较高的增值税水平随着时间的推移在绝经后妇女。需要努力推广这些研究结果。
BackgroundObesity is a leading risk factor for chronic diseases, potentially related to excess abdominal adiposity. Phthalates are environmental chemicals that have been suggested to act as obesogens, driving obesity risk. For the associations between phthalates and adiposity, prior studies have focused primarily on body mass index. We hypothesize that more refined measures of adiposity and fat distribution may provide greater insights into these associations given the role of central adiposity in chronic disease risk.ObjectivesTo evaluate associations between urinary phthalate biomarkers and both visceral and subcutaneous adipose tissue (VAT and SAT) among postmenopausal women enrolled in the Women's Health Initiative (WHI).MethodsWe included 1125 WHI participants with available, coincident measurements of urinary phthalate biomarkers (baseline, year 3) and VAT and SAT (baseline, year 3, year 6). VAT and SAT measurements were estimated from DXA scans. Multilevel mixed-effects models estimated the prospective associations between urinary phthalate biomarkers at baseline and VAT and SAT three years later.ResultsIn multivariable adjusted models, we observed positive associations between some phthalate biomarkers, including the sum of di-isobutyl phthalate (ΣDiBP) biomarkers, MCNP, and ΣDEHP, with VAT three years later. For example, we observed positive associations between concentrations of ΣDiBP and VAT (Q4 vs Q1 β = 7.15, 95% CI -1.76-16.06; Q3 vs Q1 β = 10.94, 95% CI 3.55–18.33). Associations were generally attenuated but remained significant after additional adjustment for SAT. MBzP was positively associated with SAT. Other phthalate biomarkers investigated (MEP, MCOP, MCPP, ΣDBP) were not significantly associated with VAT or SAT.DiscussionBased on robust measures of adiposity, this study provides supportive evidence that higher urinary concentrations of select phthalate compounds were associated with higher VAT levels over time in postmenopausal women. Efforts to replicate these findings are needed.