D3 dopamine receptors do not regulate neurogenesis in the subventricular zone of adult mice
D3 dopamine receptors do not regulate neurogenesis in the subventricular zone of adult mice
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DOI：
10.1016/j.nbd.2005.01.004
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发表时间：
2005-04-01
影响因子：
6.1
通讯作者：
Hagg, T
中科院分区：
文献类型：
--
作者：
Baker, SA;Baker, KA;Hagg, T
在不同物种中测试刺激内源性神经发生的药物对人类神经修复策略的发展具有重要意义。我们之前在成年大鼠中发现，14天脑室内灌注D3优先激动剂7-羟基二丙基氨基四氨酸（7- o- dpat）可增加前侧脑室（SVZ）室下区神经前体的BrdU标记。在这里，我们发现即使在高剂量或注入新纹状体时，这种治疗也未能影响C57B1/6和FVB小鼠的神经发生。我们证实这种治疗对成年大鼠有效。此外，D3受体抑制或基因敲除对小鼠神经发生没有影响。这些结果提出了神经发生不是由所有物种的D3受体调节的可能性，因此，D3激动剂如普拉克索可能不适用于帕金森病的细胞替代策略中利用内源性神经发生。(c) 2005爱思唯尔公司版权所有。
Testing the effects of drugs that stimulate endogenous neurogenesis in different species is important for the development of neural repair strategies in humans. We have previously shown in adult rats that a 14-day intracerebroventricular infusion of the D3 preferential agonist 7-hydroxydipropyl-amino-tetraline (7-OH-DPAT) increases BrdU labeling of neural precursors in the subventricular zone of the anterior lateral ventricle (SVZ). Here, we show that such a treatment failed to affect neurogenesis in C57B1/6 and FVB mice, even at a high dose or when infused into the neostriatum. We confirmed that such a treatment was effective in adult rats. Moreover, D3 receptor inhibition or genetic knockout failed to affect the neurogenesis in mice. These results raise the possibilities that neurogenesis is not regulated by D3 receptors in all species and, therefore, that D3 agonists like pramipexole may not be useful to harness endogenous neurogenesis in cell replacement strategies for Parkinson's disease. (c) 2005 Elsevier Inc. All rights reserved.