Low-level environmental metals and metalloids and incident pregnancy loss.
Low-level environmental metals and metalloids and incident pregnancy loss.
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DOI：
10.1016/j.reprotox.2017.01.011
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发表时间：
2017-04
期刊：
影响因子：
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通讯作者：
Parsons PJ
中科院分区：
文献类型：
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作者：
Buck Louis GM;Smarr MM;Sundaram R;Steuerwald AJ;Sapra KJ;Lu Z;Parsons PJ
在一些但不是所有的研究中，金属和类金属的环境暴露与妊娠丢失有关。我们评估了501对夫妇在尝试怀孕时的砷、镉、汞和铅浓度，并在整个怀孕期间对其进行随访，以估计意外流产的风险。使用考克斯比例风险模型，我们估计了协变量调整后的妊娠丢失的风险比（HR）和95%置信区间（CI），分别为每个伴侣建模，然后我们联合建模两个伴侣的浓度。流产率为28%。在个体伴侣模型中，观察到女性和男性血镉的校正HR最高（HR = 1.08; CI 0.81，1.44; HR = 1.09; 95% CI 0.84，1.41）。在基于夫妇的模型中，伴侣的血镉浓度与损失无关（HR = 1.01; 95% CI 0.75，1.37; HR = 0.92; CI 0.68，1.25）。我们没有观察到任何证据表明，在环境相关浓度的金属（loids）和妊娠损失之间存在显着关系。
Environmental exposure to metals and metalloids is associated with pregnancy loss in some but not all studies. We assessed arsenic, cadmium, mercury, and lead concentrations in 501 couples upon trying for pregnancy and followed them throughout pregnancy to estimate the risk of incident pregnancy loss. Using Cox proportional hazard models, we estimated hazard ratios (HR) and 95% confidence intervals (CIs) for pregnancy loss after covariate adjustment for each partner modeled individually then we jointly modeled both partners’ concentrations. Incidence of pregnancy loss was 28%. In individual partner models, the highest adjusted HRs were observed for female and male blood cadmium (HR=1.08; CI 0.81, 1.44; HR=1.09; 95% CI 0.84, 1.41, respectively). In couple based models, neither partner’s blood cadmium concentrations were associated with loss (HR=1.01; 95% CI 0.75, 1.37; HR=0.92; CI 0.68, 1.25, respectively). We observed no evidence of a significant relation between metal(loids) at environmentally relevant concentrations and pregnancy loss.