Elevated levels of plasma Big endothelin-1 and its relation to hypertension and skin lesions in individuals exposed to arsenic
Elevated levels of plasma Big endothelin-1 and its relation to hypertension and skin lesions in individuals exposed to arsenic
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DOI：
10.1016/j.taap.2011.12.023
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发表时间：
2012-03-01
影响因子：
3.8
通讯作者：
Hossain, Khaled
中科院分区：
文献类型：
--
作者：
Hossain, Ekhtear;Islam, Khairul;Hossain, Khaled
慢性砷暴露会影响内皮系统，导致多种疾病。大内皮素-1 （Big ET-1）是内皮素-1 （ET-1）的生物前体，是内皮系统激活程度的较准确指标。砷暴露对血浆大ET-1水平的影响及其生理意义尚未见文献记载。我们评估了孟加拉砷暴露个体血浆大ET-1水平及其与高血压和皮肤病变的关系。本研究共招募了来自孟加拉国流行和非流行地区的304名研究对象。用电感耦合等离子体质谱（ICP-MS）测定了水、头发和指甲中的砷浓度。采用一步夹心酶免疫测定试剂盒测定血浆大ET-1水平。随着饮用水、头发和指甲中砷浓度的增加，观察到大ET-1水平显著增加。此外，调整不同协变量前后，血浆大ET-1水平与研究对象的水、头发和指甲As浓度显著相关。与最低（参考）暴露组相比，高暴露组的大ET-1水平也更高。有趣的是，我们观察到高血压组和皮肤病变组的大ET-1水平明显高于高血压组和无皮肤病变组，分别是as流行地区的研究对象。因此，本研究证明了砷暴露与血浆大ET-1水平之间的一种新的剂量-反应关系，表明血浆大ET-1水平可能参与砷诱导的高血压和皮肤病变。(C) 2012爱思唯尔公司版权所有。
Chronic arsenic (As) exposure affects the endothelial system causing several diseases. Big endothelin-1 (Big ET-1), the biological precursor of endothelin-1 (ET-1) is a more accurate indicator of the degree of activation of the endothelial system. Effect of As exposure on the plasma Big ET-1 levels and its physiological implications have not yet been documented. We evaluated plasma Big ET-1 levels and their relation to hypertension and skin lesions in As exposed individuals in Bangladesh. A total of 304 study subjects from the As-endemic and non-endemic areas in Bangladesh were recruited for this study. As concentrations in water, hair and nails were measured by Inductively Coupled Plasma Mass Spectroscopy (ICP-MS). The plasma Big ET-1 levels were measured using a one-step sandwich enzyme immunoassay kit. Significant increase in Big ET-1 levels were observed with the increasing concentrations of As in drinking water, hair and nails. Further, before and after adjusting with different covariates, plasma Big ET-1 levels were found to be significantly associated with the water, hair and nail As concentrations of the study subjects. Big ET-1 levels were also higher in the higher exposure groups compared to the lowest (reference) group. Interestingly, we observed that Big ET-1 levels were significantly higher in the hypertensive and skin lesion groups compared to the normotensive and without skin lesion counterpart, respectively of the study subjects in As-endemic areas. Thus, this study demonstrated a novel dose-response relationship between As exposure and plasma Big ET-1 levels indicating the possible involvement of plasma Big ET-1 levels in As-induced hypertension and skin lesions. (C) 2012 Elsevier Inc. All rights reserved.