The Past, Present, and Future of PrEP implementation Among People Who Use Drugs.

The Past, Present, and Future of PrEP implementation Among People Who Use Drugs.
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DOI:
10.1007/s11904-021-00556-z
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发表时间:
2021-08
影响因子:
4.6
通讯作者:
Bazzi AR
Bazzi AR
中科院分区:
医学2区
文献类型:
--
作者:
Biello KB;Mimiaga MJ;Valente PK;Saxena N;Bazzi AR

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最近吸毒者 (PWUD) 中艾滋病毒的爆发需要额外的艾滋病毒预防工具。暴露前预防 (PrEP) 非常有效,但 PWUD 的使用率仍然极低。为了解决残疾人士使用 PrEP 的多层次、复杂的障碍,需要采取一系列干预策略。关于优化残疾人士中 PrEP 使用的干预措施的文献才刚刚起步,包括干预措施开发早期阶段的小型试点和示范项目。初步研究表明,结构、医疗保健、人际关系和个人层面的干预措施可以改善 PWUD 中 PrEP 的使用,并且许多疗效试验正在进行中。未来的研究需要优化新的 PrEP 模式(例如注射 PrEP)的使用,同时针对 PrEP 使用的多层次挑战,并评估 PrEP 与其他服务环境和药物使用治疗模式的整合。
Recent HIV outbreaks among people who use drugs (PWUD) necessitate additional HIV prevention tools. Pre-exposure prophylaxis (PrEP) is highly efficacious yet uptake among PWUD remains exceedingly low. To address multilevel, complex barriers to PrEP use among PWUD, a range of intervention strategies are needed. The literature on interventions to optimize PrEP use among PWUD is nascent, comprising small pilots and demonstration projects in early phases of intervention development. Initial studies suggest that structural, healthcare, interpersonal, and individual-level interventions can improve PrEP use for PWUD, and a number of efficacy trials are underway. Future studies are needed to optimize the use of new PrEP modalities (e.g., injectable PrEP), simultaneously target multilevel challenges to PrEP use, and evaluate the integration of PrEP into other service settings and substance use treatment modalities.
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