Genetics of native airway responsiveness in mice.
Genetics of native airway responsiveness in mice.
复制标题
小鼠天然气道反应性的遗传学。
DOI：
10.1164/ajrccm.156.4.12-tac-2
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发表时间：
1997
期刊：
影响因子：
--
通讯作者：
Drazen,JM
中科院分区：
文献类型：
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作者：
DeSanctis,GT;Drazen,JM
近交系小鼠是剖析简单和复杂性状的有力工具。对小鼠的遗传学研究应确定与人类相同的生化途径中起作用的疾病基因。与遗传异质性相关的问题，无法控制环境条件，缺乏丰富的遗传标记供应，以及关于人类遗传杂交的伦理考虑，只是研究小鼠气道反应性的一些原因。目前，只有少数研究揭示了气道反应性的遗传学;更少的研究试图确定调节这一特征的遗传基因座。很明显，遗传和环境因素都影响哮喘表型，遗传背景是解释分离分析数据时的重要考虑因素。关于数量性状基因座（QTL）的具体遗传方式、数量和位置的争论说明了进一步研究的必要性。 然而，考虑到在最近的两项研究中发现的与哮喘发病机制有关的许多候选基因座位于QTL附近，并且考虑到人类和小鼠基因组之间的相当大的同源性，有必要在人类中靶向搜索易感基因。理想情况下，这些区域将在人类中表现出联系。因此，进一步的工作仍有待完成，以创建详细的地图，在小鼠中的连锁区域，并最终确定基因，修改气道反应性。De Sanctis GT，Drazen JM.小鼠天然气道反应性的遗传学研究。
The inbred mouse represents a powerful tool for dissecting both simple and complex traits. Genetic studies in the mouse should identify disease genes acting in the same biochemical pathway as in the human. Problems associated with genetic heterogeneity, inability to control environmental conditions, lack of an abundant supply of genetic markers, and ethical considerations regarding human genetic crosses are but some of the reasons to study airway responsiveness in the mouse. At present, only a handful of studies have shed light on the genetics of airway responsiveness; even fewer have sought to identify genetic loci that regulate this trait. It is clear that both genetic and environmental factors influence the asthma phenotype and that genetic background is an important consideration when interpreting segregation analysis data. The controversy over the specific mode of inheritance and number and location of quantitative trait loci (QTL) illustrates the need for additional studies. However, given that numerous candidate loci implicated in the pathogenesis of asthma map near QTLs identified in two recent studies, and given the considerable homology between the human and mouse genome, a targeted search for susceptibility genes is warranted in the human. Ideally, these regions will demonstrate linkage in humans. Thus, further work remains to be done to create detailed maps of the regions of linkage in the mouse, and to ultimately identify gene(s) that modify airway responsiveness. De Sanctis GT, Drazen JM. Genetics of native airway responsiveness in mice.