BASIC FIBROBLAST GROWTH-FACTOR (FGF) PROMOTES CARTILAGE REPAIR INVIVO
BASIC FIBROBLAST GROWTH-FACTOR (FGF) PROMOTES CARTILAGE REPAIR INVIVO
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DOI：
10.1016/s0006-291x(88)80887-8
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发表时间：
1988-10-31
影响因子：
3.1
通讯作者：
BAIRD, A
中科院分区：
文献类型：
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作者：
CUEVAS, P;BURGOS, J;BAIRD, A
尽管已经清楚地确定碱性成纤维细胞生长因子（FGF）是体外软骨细胞的有效有丝分裂原，但几乎没有证据表明它可以在体内刺激这种细胞类型。为了解决这个问题，我们研究了碱性FGF关节内给药的效果。Alzet渗透泵通过刺激软骨细胞增殖和细胞外基质的形成，将有丝分裂原输送到损伤部位，促进髓内损伤的愈合。碱性FGF的慢性输注可以在损伤部位引起修复反应的观察结果表明，这种生长因子可能具有超出其诱导新血管形成能力的治疗应用。结果还表明，软骨膜介导软骨修复的方式之一可能是通过局部产生FGF样有丝分裂原。
Although it has been clearly established that basic fibroblast growth factor (FGF) is a potent mitogen for chondrocytes in vitro, there is little evidence that it can stimulate this cell type in vivo. In an effort to address this problem, we examined the effect of an intraarticular administration of basic FGF. Alzet osmotic pumps delivering the mitogen to the site of injury promotes the healing of intra-chondrial lesions by stimulating chondrocyte proliferation and the formation of extracellular matrix. The observation that chronic infusions of basic FGF can elicit a repair response at the site of injury suggests that this growth factor may have therapeutic applications that extend beyond its capacity to induce neovascularization. The results also suggest that one of the ways that the perichondrium mediates cartilage repair may be by the local production of FGF-like mitogens.