Interactive Relations Across Dimensions of Interpersonal-Level Discrimination and Depressive Symptoms to Carotid Intimal-Medial Thickening in African Americans.
Interactive Relations Across Dimensions of Interpersonal-Level Discrimination and Depressive Symptoms to Carotid Intimal-Medial Thickening in African Americans.
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DOI：
10.1097/psy.0000000000000765
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发表时间：
2020
影响因子：
3.3
通讯作者：
Zonderman, Alan B.
中科院分区：
文献类型：
--
作者：
Beatty Moody, Danielle L.;Leibel, Daniel K.;Pantesco, Elizabeth J.;Wendell, Carrington R.;Waldstein, Shari R.;Evans, Michele K.;Zonderman, Alan B.
关键词：
atherosclerosishealth disparitiesintimal-medial thicknesssubclinical vascular diseaserisk factorspsychosocial vulnerabilitiesBMI = body mass indexCES-D = Center for Epidemiologic Studies Depression scaleHANDLS = Healthy Aging in Neighborhoods of Diversity across the Life SpanIMT = intimal-medial thicknessMRV = medical research vehicleSES = socioeconomic status
这项研究的目的是在中年到老年的非裔美国人和白人中，研究自我报告的歧视的多个维度与抑郁症状的多个维度之间的相互作用与颈动脉内膜-中层厚度(IMT)的关系，IMT是动脉粥样硬化的亚临床标记物，预期与中风的发病率有关。参与者包括1941名非洲裔美国人(56.5%)和接受颈动脉IMT测量的白人(30-，47%的男性，45.2%的家庭收入和125%的联邦贫困线)。对歧视进行了四个方面的评估(每天、不同社会地位的频率、种族和终身负担)。采用流行病学研究中心抑郁量表评估抑郁症状。在横断面分层回归分析中，在非裔美国人中观察到了两种交互作用：不同社会地位的更频繁的歧视(b<；0.001，p=.006)和终生更高的歧视负担(b<；0.001，p=0.02)都与抑郁症状较重的人颈动脉内膜厚度有关。在白人体内没有观察到显著的发现。在非裔美国人中，那些报告高水平歧视和抑郁症状的人增加了颈动脉粥样硬化，与那些报告这些危险因素中的一个或两者都不报告的人相比，他们可能面临更大的临床终点风险。研究结果表明，对社会和心理因素之间相互作用关系的评估可能会阐明非裔美国人中包括中风在内的心血管疾病的新途径。
This study aimed to examine within-race interactions of multiple dimensions of self-reported discrimination with depressive symptoms in relation to carotid intimal-medial thickness (IMT), a subclinical marker of atherosclerosis prospectively implicated in stroke incidence, in middle-aged to older African American and white adults. Participants were a socioeconomically diverse group of 1941 African Americans (56.5%) and whites from the Healthy Aging in Neighborhoods of Diversity across the Life Span study (30–64 years old, 47% men, 45.2% with household income <125% federal poverty threshold) who underwent carotid IMT measurement. Discrimination was assessed across four dimensions (everyday, frequency across various social statuses, racial, and lifetime burden). The Center for Epidemiologic Studies Depression scale was used to assess depressive symptoms. In cross-sectional hierarchical regression analyses, two interactions were observed in African Americans: more frequent discrimination across various social statuses (b < 0.001, p = .006) and a higher lifetime discrimination burden (b < 0.001, p = .02) were each related to thicker carotid IMT in those with greater depressive symptoms. No significant findings were observed within whites. Among African Americans, those reporting high levels of discrimination and depressive symptoms have increased carotid atherosclerosis and may be at greater risk for clinical end points compared with those reporting one or neither of these risk factors. Findings suggest that assessment of interactive relationships among social and psychological factors may elucidate novel pathways for cardiovascular disease, including stroke, among African Americans.