Identification of Hsa_circ_0104824 as a Potential Biomarkers for Breast Cancer.
Identification of Hsa_circ_0104824 as a Potential Biomarkers for Breast Cancer.
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鉴定 Hsa_circ_0104824 作为乳腺癌的潜在生物标志物
DOI：
10.1177/1533033820960745
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发表时间：
2020-01
影响因子：
2.8
通讯作者：
Wang L
中科院分区：
文献类型：
--
作者：
Li X;Ma F;Wu L;Zhang X;Tian J;Li J;Cao J;Ma Y;Zhang L;Wang L
背景资料：目的研究乳腺癌组织及癌旁正常组织中环状RNA（circRNA）的特异性表达，寻找乳腺癌患者circRNA的差异表达。研究circRNA与乳腺癌临床资料的相关性，评价其作为乳腺癌生物标志物的潜力。研究方法：利用人CircRNA微阵列筛选乳腺癌组织与癌旁正常组织之间CircRNA的差异表达。通过qRT-PCR验证的候选circRNA。通过Agilent GeneSpring 13.0软件分析CircRNA。采用SPSS23.0、GraphPad Prism和Sigmaplot软件进行统计学分析。采用T检验、单因素方差分析、曲线回归分析和ROC曲线分析评价环状RNA的诊断价值。结果：在2021个差异表达的circRNA中，546个在乳腺癌组织中表达上调，1475个表达下调。验证研究表明，6个circRNA被下调。其中，hsa_circ_0104824在乳腺癌组织和血浆样本中的表达和诊断价值具有高度相关性。结论：Hsa_circ_0104824可作为乳腺癌的预测性生物标志物和治疗靶点。
Background: To study the specific expression of circular RNA (circRNA) in breast cancer and adjacent normal tissues to identify differentially expressed circRNA in breast cancer patients. To study the correlation between circRNA and clinical data of breast cancer, and to evaluate its potential as a breast cancer biomarker. Methods: The differential expression of circRNAs between the breast cancer tissues and adjacent normal tissues was screened by Human CircRNA Microarray. Candidate circRNAs verified by qRT-PCR. CircRNA was analyzed by Agilent GeneSpring 13.0 software. SPSS23.0, GraphPad Prism, and Sigmaplot software were used for statistical analysis. Perform T test, one-way ANOVA, curve regression analysis and ROC curve analysis for evaluating the diagnostic value of circular RNA. Results: Among the 2021 differentially expressed circRNAs, 546 were up-regulated and 1475 were down-regulated in breast cancer tissues. The validation study demonstrated that six circRNAs were downregulated. Among them, hsa_circ_0104824 proved high correlation between breast cancer tissues and plasma samples in its expression and diagnostic value. Conclusion: Hsa_circ_0104824 may serve as a promising predictive biomarker and therapeutic target for patients with breast cancer.
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