Return to the fetal gene program: a suggested metabolic link to gene expression in the heart.
Return to the fetal gene program: a suggested metabolic link to gene expression in the heart.
复制标题
返回到胎儿基因程序：建议与心脏中基因表达的代谢联系。
DOI：
10.1111/j.1749-6632.2009.05100.x
复制
发表时间：
2010-02
影响因子：
5.2
通讯作者：
Vela D
中科院分区：
文献类型：
--
作者：
Taegtmeyer H;Sen S;Vela D
A hallmark of cardiac metabolism before birth is the predominance of carbohydrate use for energy provision. After birth, energy substrate metabolism rapidly switches to the oxidation of fatty acids. This switch accompanies the expression of “adult” isoforms of metabolic enzymes and other proteins. However, in a variety of pathophysiologic conditions, including hypoxia, ischemia, hypertrophy, atrophy, diabetes, and hypothyroidism, the postnatal heart returns to the “fetal” gene program. These adaptive mechanisms are also a feature of the failing heart muscle, where at a certain point this fetal-like reprogramming no longer suffices to support cardiac structure and function. We advance the hypothesis that in the postnatal heart, metabolic remodeling triggers the process through glycosylation of transcription factors, potentially protecting the stressed heart from irreversible functional impairment and programmed cell death. In other words, we propose a metabolic link to gene expression in the heart.
登录
查看更多内容
影响因子：
37.8
作者：
Razeghi, P;Young, ME;Taegtmeyer, H
通讯作者：
Taegtmeyer, H
DOI：
10.1006/bbrc.2001.5541
发表时间：
2001-09-14
影响因子：
3.1
作者：
Razeghi, P;Young, ME;Taegtmeyer, H
通讯作者：
Taegtmeyer, H
影响因子：
10.5
作者：
Gottlob, K;Majewski, N;Hay, N
通讯作者：
Hay, N
影响因子：
37.8
作者：
Dewald, O;Sharma, S;Taegtmeyer, H
通讯作者：
Taegtmeyer, H
影响因子：
15.9
作者：
Nakao, K;Minobe, W;Leinwand, LA
通讯作者：
Leinwand, LA