Intracavernous pressure responses to physical and electrical stimulation of the cavernous nerve in rats
Intracavernous pressure responses to physical and electrical stimulation of the cavernous nerve in rats
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DOI：
10.1016/s0090-4295(97)00693-6
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发表时间：
1998-04-01
期刊：
影响因子：
2.1
通讯作者：
Fleischmann, J
中科院分区：
文献类型：
--
作者：
Rehman, J;Christ, G;Fleischmann, J
目标.为了更好地定义保留神经的前列腺切除术，这将导致保留勃起功能的技术，我们描述了物理压力对前列腺和海绵体神经的影响，海绵体神经的电刺激，以及对正常和糖尿病大鼠海绵体内压（ICP）的药理学操作。Fischer-34大鼠，正常和糖尿病，进行解剖，分离海绵体和海绵体神经。海绵体压力的特点是在手术操作过程中，在电刺激海绵体神经，并在盐酸罂粟碱注射。在正常大鼠中，基线海绵体压力范围为5至15 cm H2O（平均12.29）。在糖尿病大鼠中，基线压力显著较低（3至7.5 cm H2O）。侧神经移位导致ICP上升到约35厘米H2O在正常大鼠，但只有20厘米H2O在糖尿病大鼠。电刺激导致正常大鼠海绵体压力从基线增加10倍，糖尿病大鼠从基线增加7倍。保留神经的解剖技术不会明显干扰ICP。神经切断术导致所有大鼠的基线海绵体压力下降。电刺激切断的神经的远端导致压力上升到在具有完整海绵体神经的大鼠中观察到的压力的50%。在神经刺激之前或之后的海绵体内注射罂粟碱掩盖了随后的（预期的）压力变化。海绵体压力的变化是海绵体神经操作的敏感指标。海绵体压力测量和海绵体神经的电刺激都可以在根治性切除术中帮助外科医生。(C)1998年，Elsevier Science Inc.保留所有权利。
Objectives. To better define the techniques of nerve-sparing prostate dissection that would result in preservation of erectile function, we characterize the effects of physical pressure on the prostate and cavernous nerve, electrical stimulation of the cavernous nerve, and pharmacologic manipulations on intracavernous pressure (ICP) in normal and diabetic rats.Methods. Fischer-34 rats, both normal and diabetic, underwent dissections that isolated the cavernous bodies and cavernous nerves. Cavernous body pressures were characterized during surgical manipulation, during electrical stimulation of the cavernous nerves, and following papaverine hydrochloride injection.Results. In normal rats, baseline cavernous pressures ranged from 5 to 15 cm H2O (mean 12.29). In diabetic rats, the baseline pressure was significantly lower (3 to 7.5 cm H2O). Lateral nerve displacement caused ICP to rise to approximately 35 cm H2O in normal rats, but only to 20 cm H2O in diabetic rats. Electrostimulation resulted in cavernous pressure increases of 10-fold from baseline in normal rats and sevenfold from baseline in diabetic rats. ICPs were not disturbed appreciably with nerve-sparing dissection techniques. Neurotomy resulted in declines in baseline cavernous pressures in all rats. Electrostimulation of the distal end of a severed nerve resulted in pressure rises to 50% of those observed in rats with intact cavernous nerves. Intracavernous papaverine injection before or after nerve stimulation masked subsequent (expected) pressure changes.Conclusions. A change in cavernous pressure is a sensitive indicator of cavernous nerve manipulation. Both cavernous pressure measurements and electrostimulation of cavernous nerves may aid surgeons during radical prostatectomy. (C) 1998, Elsevier Science inc. Ail rights reserved.