A comprehensive survey of cadherin superfamily gene expression patterns in Ciona intestinalis
A comprehensive survey of cadherin superfamily gene expression patterns in Ciona intestinalis
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DOI：
10.1016/j.gep.2008.01.004
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发表时间：
2008-05-01
影响因子：
1.2
通讯作者：
Satoh, Nori
中科院分区：
文献类型：
--
作者：
Noda, Takeshi;Satoh, Nori
我们对钙粘蛋白超家族基因在基底层肠索动物中的时空表达进行了全面的研究，作为直接调控细胞形态发生过程的基因家族的全基因组表达研究的例子。我们发现有15个钙粘蛋白超家族基因在肠上皮细胞基因组中有明确表达。直到原肠胚晚期，所有已鉴定的β-原钙粘附素和II型经典钙粘附素都得到了合子表达，而其他亚家族成员则不表达。然而，在后期，所有钙粘附素超家族基因都在神经系统中表达。这些数据有助于理解这些基因在脊索动物发育和脊索动物进化中的作用。(C)2008爱思唯尔B.V.保留所有权利。
We have carried out a comprehensive survey of the spatiotemporal expression of cadherin superfamily genes in the basal chordate Ciona intestinalis, as an example of a genome-wide expression study of a gene family directly regulating cellular processes in morphogenesis. We found 15 definitely expressed cadherin superfamily genes in the Ciona intestinalis genome. Up to the late gastrula stage, all identified delta-protocadherins and the type II classical cadherin, but not other subfamily members, were zygotically expressed. At later stages, however, all cadherin superfamily genes were expressed in the nervous system. These data are useful for understanding the role of these genes in Ciona development and the evolution of chordates. (c) 2008 Elsevier B.V. All rights reserved.