Altered functional connectivity in the motor network after traumatic brain injury
Altered functional connectivity in the motor network after traumatic brain injury
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DOI：
10.1212/wnl.0b013e3181e7ca58
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发表时间：
2010-07-13
期刊：
影响因子：
9.9
通讯作者：
Stamatakis, E. A.
中科院分区：
文献类型：
--
作者：
Kasahara, M.;Menon, D. K.;Stamatakis, E. A.
背景资料：大部分创伤性脑损伤（TBI）的幸存者具有持续的认知障碍，其特征并不总是与损伤的大小和位置相对应。一种可能的解释是TBI引起的损伤超出了明显的损伤部位，影响了远程大脑网络。我们在一个简单且特征明确的网络--运动网络--的背景下探讨了这一假设。本横断面研究的目的是建立运动网络的剩余完整性作为TBI.Methods异常连接原则的重要证据：从12名右利手患者和9名健康对照组中获得fMRI数据，而他们进行的手指拇指反对任务与右手。我们使用了传统的和心理生理学的相互作用（PPI）分析，以检查从大脑区域的功能连接的完整性，我们发现被激活的paradigm we used.Results：正如预期的那样，分析显示显着激活的左侧初级运动皮层（M1），右侧小脑（Ce），和双边补充运动区（SMA）在控制。然而，只有M1的激活在患者中存活了稳健的统计阈值。在对照组中，PPI分析显示，左侧M1，SMA和右侧Ce与左侧额叶皮质呈正相关，与右侧缘上回呈负相关。在患者中，我们没有观察到负面的相互作用，减少interhemispheric的相互作用，从这些seed regions.Conclusions：这些观察结果表明，患者显示受损的激活和连接模式，在手指拇指反对任务，这可能意味着功能重组的运动网络TBI。神经病学（R）2010;75：168-176
Background: A large proportion of survivors of traumatic brain injury (TBI) have persistent cognitive impairments, the profile of which does not always correspond to the size and location of injuries. One possible explanation could be that TBI-induced damage extends beyond obvious lesion sites to affect remote brain networks. We explored this hypothesis in the context of a simple and well-characterized network, the motor network. The aim of this cross-sectional study was to establish the residual integrity of the motor network as an important proof of principle of abnormal connectivity in TBI.Methods: fMRI data were obtained from 12 right-handed patients and 9 healthy controls while they performed the finger-thumb opposition task with the right hand. We used both conventional and psychophysiologic interaction (PPI) analyses to examine the integrity of functional connections from brain regions we found to be activated in the paradigm we used.Results: As expected, the analysis showed significant activations of the left primary motor cortex (M1), right cerebellum (Ce), and bilateral supplementary motor area (SMA) in controls. However, only the activation of M1 survived robust statistical thresholding in patients. In controls, the PPI analysis revealed that left M1, SMA, and right Ce positively interacted with the left frontal cortex and negatively interacted with the right supramarginal gyrus. In patients, we observed no negative interaction and reduced interhemispheric interactions from these seed regions.Conclusions: These observations suggest that patients display compromised activation and connectivity patterns during the finger-thumb opposition task, which may imply functional reorganization of motor networks following TBI. Neurology(R) 2010;75:168-176